Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction for the HRRT

Carson, Richard E.; Barker, William; Liow, Jeih‐San; Johnson, Calvin A.

doi:10.1109/nssmic.2003.1352597

Cited by 199 publications

(201 citation statements)

References 11 publications

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“…as a bolus over 1 min by a computer-controlled pump (Harvard Apparatus), and emission data were collected for 120 min. Dynamic list-mode scan data were reconstructed into 33 frames (6 × 30 s, 3 × 1 min, 2 × 2 min, and 22 × 5 min) with all corrections (i.e., attenuation, normalization, randoms, scatter, deadtime, and motion) using the ordered-subset expectation maximization (OSEM)-based MOLAR algorithm (60). The final reconstructed image resolution was ∼3 mm.…”

Section: Methodsmentioning

confidence: 99%

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Sandiego

Gallezot

Pittman

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

280

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Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopolysaccharide (LPS; also called endotoxin) in humans with the positron emission tomography (PET) radiotracer [ 11 C]PBR28, which binds to translocator protein, a molecular marker that is up-regulated by microglial activation. In addition, inflammatory cytokines in serum and sickness behavior profiles were measured before and after LPS administration to relate brain microglial activation with systemic inflammation and behavior. Eight healthy male subjects each had two 120-min [ 11 C]PBR28 PET scans in 1 d, before and after an LPS challenge. LPS (1.0 ng/kg, i.v.) was administered 180 min before the second [ 11 C]PBR28 scan. LPS administration significantly increased [ 11 C]PBR28 binding 30-60%, demonstrating microglial activation throughout the brain. This increase was accompanied by an increase in blood levels of inflammatory cytokines, vital sign changes, and sickness symptoms, well-established consequences of LPS administration. To our knowledge, this is the first demonstration in humans that a systemic LPS challenge induces robust increases in microglial activation in the brain. This imaging paradigm to measure brain microglial activation with [ 11 C]PBR28 PET provides an approach to test new medications in humans for their putative antiinflammatory effects.neuroinflammation | PBR28 | endotoxin | microglia | cytokines

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Section: Methodsmentioning

confidence: 99%

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Sandiego

Gallezot

Pittman

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

280

220

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“…Dynamic PET imaging data were reconstructed with corrections for attenuation, normalization, scatter, randoms, deadtime, and motion employing the MOLAR algorithm (Carson et al, 2003) with a frame timing of 6 × 30 s; 3 × 1 min; 2 × 2 min; and 22 × 5 min.…”

Section: Methodsmentioning

confidence: 99%

Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO

Gaiser

Gallezot

Worhunsky

et al. 2016

Neuropsychopharmacol

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Most prior work with positron emission tomography (PET) dopamine subtype 2/3 receptor (D 2/3 R) non-selective antagonist tracers suggests that obese (OB) individuals exhibit lower D 2/3 Rs when compared with normal weight (NW) individuals. A D 3 -preferring D 2/3 R agonist tracer, [ 11 C](+)PHNO, has demonstrated that body mass index (BMI) was positively associated with D 2/3 R availability within striatal reward regions. To date, OB individuals have not been studied with [ 11 C](+)PHNO. We assessed D 2/3 R availability in striatal and extrastriatal reward regions in 14 OB and 14 age-and gender-matched NW individuals with [ 11 C](+)PHNO PET utilizing a high-resolution research tomograph. Additionally, in regions where group D 2/3 R differences were observed, secondary analyses of 42 individuals that constituted an overweight cohort was done to study the linear association between BMI and D 2/3 R availability in those respective regions. A group-by-brain region interaction effect (F 7, 182 = 2.08, p= 0.047) was observed. Post hoc analyses revealed that OB individuals exhibited higher tracer binding in D 3 -rich regions: the substantia nigra/ventral tegmental area (SN/VTA) (+20%; p = 0.02), ventral striatum (VST) (+14%; po0.01), and pallidum (+11%; p = 0.02). BMI was also positively associated with D 2/3 R availability in the SN/VTA (r = 0.34, p = 0.03), VST (r = 0.36, p = 0.02), and pallidum (r = 0.30, p = 0.05) across all subjects. These data suggest that individuals who are obese have higher D 2/3 R availability in brain reward regions densely populated with D 3 Rs, potentially identifying a novel pharmacologic target for the treatment of obesity.

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“…Listmode dynamic scan data were collected and reconstructed (reconstructed image resolution B3 mm) with all corrections (randoms, scatter, dead time, attenuation, normalization, and motion) by the MOLAR algorithm. 20 In addition to the event-by-event motion correction performed during the reconstruction, software motion correction was also performed by registering each frame to an early summed image (0 to 10 minutes) using FLIRT (FSL 3.2, Analysis Group, FMRIB, Oxford, UK).…”

Section: Positron Emission Tomography Imagingmentioning

confidence: 99%

Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [¹⁸F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans

Sullivan

Lim

Labaree

et al. 2012

J Cereb Blood Flow Metab

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[ 18 F]FPEB is a positron emission tomography tracer which, in preclinical studies, has shown high specificity and selectivity toward the metabotropic glutamate receptor 5 (mGluR5). It possesses the potential to be used in human studies to evaluate mGluR5 function in a range of neuropsychiatric disorders, such as anxiety and Fragile X syndrome. To define optimal scan methodology, healthy human subjects were scanned for 6 hours following either a bolus injection (n ¼ 5) or bolus-plus-constant-infusion (n ¼ 5) of [ 18 F]FPEB. Arterial blood samples were collected and parent fraction measured by high-performance liquid chromatography (HPLC) to determine the metabolite-corrected plasma input function. Time activity curves were extracted from 13 regions and fitted by various models to estimate V T and BP ND . [ 18 F]FPEB was well fitted by the two-tissue compartment model, MA1 (t* ¼ 30), and MRTM (using cerebellum white matter as a reference). Highest V T values were observed in the anterior cingulate and caudate, and lowest V T values were observed in the cerebellum and pallidum. For kinetic modeling studies, V T and BP ND were estimated from bolus or bolus-plus-constant-infusion scans as short as 90 minutes. Bolus-plus-constant-infusion of [ 18 F]FPEB reduced intersubject variability in V T and allowed equilibrium analysis to be completed with a 30-minute scan, acquired 90-120 minutes after the start of injection.

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Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction for the HRRT

Cited by 199 publications

References 11 publications

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO

Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [¹⁸F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans

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Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction for the HRRT

Cited by 199 publications

References 11 publications

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO

Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [18F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans

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Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [¹⁸F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans