Design of a facile, green and efficient graphene oxide-based electrochemical sensor for analysis of acetaminophen drug

Abstract

In this study an efficient and environment friendly electrochemical sensor has been designed for the analysis of acetaminophen (APAP) drug. Electrochemical impedance spectroscopy, differential pulse voltammetry and cyclic voltammetric techniques were used to demonstrate the fabricated erGO/GCE sensor performance. Voltammetric assessment of acetaminophen drug was done using bare GC electrode, drop-casted GO/GC electrode and erGO/GCE electrochemical sensor. Proposed sensor was precisely validated for APAP detection by differential pulse voltammetric technique. Subsequently LOD, LOQ, sensitivity and linearity were determined and found to be 7.23 nM, 21.909 nM, 20.14 μA nM −1 cm −2 and 0.0219–2.30 μM, respectively. The diffusion coefficient of APAP was determined by chronoamperometry, and it was found to be 2.24 × 10 –5 cm 2 .s −1 . The synthetic and analytical steps were assessed as per the Green Chemistry’s 12 Principles giving a 66 score (acceptable) and 93 score (excellent) for the said steps, respectively. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11696-022-02628-9.

Fe–Decorated Nitrogen–Doped Carbon Nanospheres as an Electrochemical Sensing Platform for the Detection of Acetaminophen

“…The fitted data yielded charge transfer resistances (Rct) of 187.4 Ω, 164.9 Ω, 105.4 Ω, 10.6 Ω, and 34.7 Ω for Bare GCE, NC–800/GCE, Fe–NC–700/GCE, Fe–NC–800/GCE, and Fe–NC–900/GCE, respectively. The charge transfer resistance is inversely proportional to the capacitance [ 34 ]. The value of Rct confirms the conductive nature of Fe–NC–800, which promotes a faster electron transfer [ 35 ], in agreement with the CV data in Figure S2A .…”