Design of a core-shelled polymer cylinder for potential programmable drug delivery

Qiu, Liyan; Zhu, Kan

doi:10.1016/s0378-5173(01)00644-5

Cited by 20 publications

(4 citation statements)

References 16 publications

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“…Bioerodible polymers are ideal for a variety of biomedical applications. Their chemistries can be tailored to stabilize macromolecular drugs, their surfaces can be modified to target delivery to specific cells and tissues, and their erosion kinetics can be modulated by a variety of techniques. − Bioerodible polymers have been used to fabricate scaffolds for tissue engineering, , implants for orthopedic applications, and vehicles for targeted and controlled drug delivery. − In all of these applications, the erosion kinetics is key to the performance of the device. The erosion kinetics can be modulated by altering copolymer composition when the two constituent polymers erode at different rates or by changing the crystallinity when crystalline and amorphous domains erode at different rates.…”

Section: Introductionmentioning

confidence: 99%

Molecular Description of Erosion Phenomena in Biodegradable Polymers

Kipper

Narasimhan

2005

Macromolecules

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A new model for the erosion kinetics of semicrystalline surface-erodible homopolymers and copolymers is presented. The model is derived for a class of surface-erodible polyanhydride copolymers, with the goal of describing erosion in terms of fundamental, elementary processes. This model is based on an accurate description of copolymer microstructure and can thereby account for the heterogeneous erosion due to microphase separation and crystallinity. In addition to accurately predicting the overall erosion profile and the release of individual monomer species, several key phenomena that occur during erosion are described. These include precipitation of slightly soluble degradation products inside the pores of the erosion zone and pH changes during erosion due to dissolution of acidic monomers and the consequent changes in monomer solubility. This model also motivates future experiments to investigate predicted phenomena such as the effects due to local changes in pH and degradation rate constants for crystalline and amorphous moieties. The rational design of biomedical devices such as vehicles for drug delivery and scaffolds for tissue engineering will be aided by the application of this model and future extensions of it. Received November 13, 2004; Revised Manuscript Received December 13, 2004 ABSTRACT: A new model for the erosion kinetics of semicrystalline surface-erodible homopolymers and copolymers is presented. The model is derived for a class of surface-erodible polyanhydride copolymers, with the goal of describing erosion in terms of fundamental, elementary processes. This model is based on an accurate description of copolymer microstructure and can thereby account for the heterogeneous erosion due to microphase separation and crystallinity. In addition to accurately predicting the overall erosion profile and the release of individual monomer species, several key phenomena that occur during erosion are described. These include precipitation of slightly soluble degradation products inside the pores of the erosion zone and pH changes during erosion due to dissolution of acidic monomers and the consequent changes in monomer solubility. This model also motivates future experiments to investigate predicted phenomena such as the effects due to local changes in pH and degradation rate constants for crystalline and amorphous moieties. The rational design of biomedical devices such as vehicles for drug delivery and scaffolds for tissue engineering will be aided by the application of this model and future extensions of it.

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Section: Introductionmentioning

confidence: 99%

Molecular Description of Erosion Phenomena in Biodegradable Polymers

Kipper

Narasimhan

2005

Macromolecules

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“…More recent studies demonstrating the suitability of polyanhydrides for use in single dose vaccines involved the design of a core-shelled cylindrical device composed of a biodegradable hydrophobic coating and laminated core of polyanhydrides and polyphosphazenes. 227 Polyanhydrides based on SA were used as isolating layers of the cylinder in order to produce a pulsatile drug release, a mechanism which would minimize doses of vaccines. Even though these polyanhydride systems showed promising characteristics for vaccines design, no further in vivo studies evaluating the characteristics of the proposed adjuvant were validated.…”

Section: Polyanhydridesmentioning

confidence: 99%

Vaccine adjuvants: Current challenges and future approaches

Wilson-Welder

Torres

Kipper

et al. 2009

Journal of Pharmaceutical Sciences

238

178

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For humans, companion animals, and food producing animals, vaccination has been touted as the most successful medical intervention for the prevention of disease in the twentieth century. However, vaccination is not without problems. With the development of new and less reactogenic vaccine antigens, which take advantage of molecular recombinant technologies, also comes the need for more effective adjuvants that will facilitate the induction of adaptive immune responses. Furthermore, current vaccine adjuvants are successful at generating humoral or antibody mediated protection but many diseases currently plaguing humans and animals, such as tuberculosis and malaria, require cell mediated immunity for adequate protection. A comprehensive discussion is presented of current vaccine adjuvants, their effects on the induction of immune responses, and vaccine adjuvants that have shown promise in recent literature.

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“…In these studies, a predictable and controlled protein release was observed from microspheres of poly[trimellitylimido-Ltyrosine-co-sebacic acid-co-1,3-bis(carboxyphenoxy)propane] and polymeric implants were well tolerated after subcutaneous implantation in rats. More recent studies demonstrating the suitability of polyanhydrides for use in single dose vaccines involved the design of a core-shelled cylindrical device composed of a biodegradable hydrophobic coating and laminated core of polyanhydrides and polyphosphazenes164 . Polyanhydrides based on SA were used as isolating layers of the cylinder in order to produce a pulsatile drug release, a mechanism which would minimize doses of vaccines.…”

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confidence: 99%

Novel amphiphilic polyanhydrides for vaccine delivery

Torres-Gonzalez

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Design of a core-shelled polymer cylinder for potential programmable drug delivery

Cited by 20 publications

References 16 publications

Molecular Description of Erosion Phenomena in Biodegradable Polymers

Molecular Description of Erosion Phenomena in Biodegradable Polymers

Vaccine adjuvants: Current challenges and future approaches

Novel amphiphilic polyanhydrides for vaccine delivery

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