Design of a Compact, Bimorph Deformable Mirror-Based Adaptive Optics Scanning Laser Ophthalmoscope

Abstract

We have designed, constructed and tested an adaptive optics scanning laser ophthalmoscope (AOSLO) using a bimorph mirror. The simulated AOSLO system achieves diffraction-limited criterion through all the raster scanning fields (6.4 mm pupil, 3° × 3° on pupil). The bimorph mirror-based AOSLO corrected ocular aberrations in model eyes to less than 0.1 μm RMS wavefront error with a closed-loop bandwidth of a few Hz. Facilitated with a bimorph mirror at a stroke of ±15 μm with 35 elements and an aperture of 20 mm, the new AOSLO system has a size only half that of the first-generation AOSLO system. The significant increase in stroke allows for large ocular aberrations such as defocus in the range of ±600° and astigmatism in the range of ±200°, thereby fully exploiting the AO correcting capabilities for diseased human eyes in the future.

Quality improvement of adaptive optics retinal images using conditional adversarial networks

“…To simulate the correction results of AO, the low-order aberrations were set to zero and the values of high-order Zernike coefficients were scaled by 0.1. For most research and commercial AO instruments [3,[27][28][29][30], the wavelength of them usually ranges from 650 nm to 850 nm, and the pupil diameter is usually chosen from 6 mm to 8 mm. To ensure that the trained network can be widely used in different AO systems, the wavelength λ in this study was assigned from 650 nm to 850 nm with a step of 10 nm, and the pupil diameter r was between 6 mm and 8 mm.…”

Bimorph deformable mirror-based adaptive optics scanning laser ophthalmoscope for the clinical design and performance

“…Moreover, this design is one of the most cost-effective DMs to date. 31,32 Integrated with this bimorph DM-based AO, we designed and built an AOSLO instrument for a clinical setting with the goal of being applicable to as many research and clinical applications as possible. First, the optical component was designed to span a 3-deg field of view (FOV) with diffraction-limited resolution.…”