Design of 3D multi-layered electrospun membranes embedding iron-based layered double hydroxide for drug storage and control of sustained release

Figueiredo, Mariana Pires; Layrac, Géraldine; Hébraud, Anne; Limousy, Lionel; Brendlé, Jocelyne; Schlatter, Guy; Constantino, Vera Regina Leopoldo

doi:10.1016/j.eurpolymj.2020.109675

Cited by 23 publications

(20 citation statements)

References 57 publications

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“…For the PEBA_Mg-Cl sample, LDH particles are surrounded by polymer fibers. Instead, for the PEBA_Zn-Cl sample, the plate-like association of LDH particles is visualized and is similar to the morphology observed for powder LDHs [ 11 , 37 ]. For the PEBA_Zn-NAP sample, surface fill failures are observed and LDH particle aggregation is no longer visualized.…”

Section: Resultssupporting

confidence: 66%

“…Materials with layer compositions Mg 4 FeAl and Zn 4 FeAl were abbreviated according to the divalent cations and the intercalated anion, Cl − or NAP, as follows: Mg-Cl, Mg-NAP, Zn-Cl or Zn-NAP (specifically) and Cl-LDH or NAP-LDH (generally). Mg-Cl and Mg-NAP samples were synthesized by the same methods previously reported [ 37 ]. Zn-Cl and Zn-NAP LDHs were prepared by the same method with the exception of the temperature value (kept at room temperature for both pristine and hybrid phases) and the NAP/(Fe 3+ + Al 3+ ) molar ratio kept equal to 1 for intercalation of NAP by ion-exchange reaction.…”

Section: Methodsmentioning

confidence: 99%

“…To the best of our knowledge, this work presents for the first time the design of composites based on PEBAX ® and LDH particles as well as the development of PEBAX ® dressings able to perform a modified drug release. [37]. Zn-Cl and Zn-NAP LDHs were prepared by the same method with the exception of the temperature value (kept at room temperature for both pristine and hybrid phases) and the NAP/(Fe 3+ + Al 3+ ) molar ratio kept equal to 1 for intercalation of NAP by ion-exchange reaction.…”

Section: Experimental Materialsmentioning

confidence: 99%

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Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

et al. 2020

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This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings.

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Section: Resultssupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Experimental Materialsmentioning

confidence: 99%

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Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

et al. 2020

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“…Nanofibers might be produced via different techniques, however, one of the most facile and low costed ones is the electrospinning technique [129,130]. The technique is based on applying a high voltage on a polymeric solution to be elongated and sputtered on a moving/fixed substrate to produce nanofibers.…”

Section: Electrospinningmentioning

confidence: 99%

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

Shoueir

El-Desouky

Rashad

et al. 2021

International Journal of Biological Macromolecules

101

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“…Another topic being of great interest is the elaboration of composites made of nanofibers and microparticles obtained by simultaneous electrospinning and electrospraying. The microparticles can bring to these materials dedicated functionalities such as controlled drug delivery [ 48 ] or magnetic or photonic stimuli responsivity for advanced nanomedicine treatments. [ 44 ] As in the case of composites made of several types of nanofibers, the online measurement of the surface potential could allow the control of the mat's composition throughout its thickness, a key parameter for the fine tuning of the drug release kinetic.…”

Section: Resultsmentioning

confidence: 99%

Measurement and Modeling of the Nanofiber Surface Potential during Electrospinning on a Patterned Collector: Toward Directed 3D Microstructuration

Liu

Hébraud

Sutter

et al. 2021

Adv Materials Inter

Self Cite

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Electrospinning allows the fabrication of microstructured mats when the nanofiber is deposited on a patterned collector made of regularly distributed protuberances. Such directed self‐assembling strategy results from the building of an electrostatic template induced by the charged deposited fiber strands suspended between the protuberances which in turn induces a field of attractive and repulsive forces that guide the deposition of the fiber during its landing. However, after a certain time of electrospinning, the microstructuration of the mat is generally subjected to modification and is eventually lost. Here, it is shown that the measurement of the surface potential above the deposited nanofibers is a powerful tool to track the evolution of the fibrous microstructuration during the fabrication. First, the electrospinning above a single and adjustable gap is deeply investigated and a model is proposed to explain the surface potential kinetics as a function of the gap size and the processed polymer solution. Then, the surface potential kinetics are correlated with the evolution of the 3D microstructuration in the case of electrospinning on a micropatterned collector. This original strategy paves the way for the controlled fabrication of 3D microstructured mats dedicated to a wide range of applications.

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Design of 3D multi-layered electrospun membranes embedding iron-based layered double hydroxide for drug storage and control of sustained release

Cited by 23 publications

References 57 publications

Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

Measurement and Modeling of the Nanofiber Surface Potential during Electrospinning on a Patterned Collector: Toward Directed 3D Microstructuration

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