Design, Implementation, Evaluation and Application of a 32-Channel Radio Frequency Signal Generator for Thermal Magnetic Resonance Based Anti-Cancer Treatment

Han, Haopeng; Eigentler, Thomas Wilhelm; Wang, Shuailin; Kretov, Egor; Winter, Lukas; Hoffmann, Werner; Grass, Eckhard; Niendorf, Thoralf

doi:10.3390/cancers12071720

Cited by 9 publications

(18 citation statements)

References 55 publications

(72 reference statements)

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“…The schematic of the experimental setup is illustrated in Figure 3 B. Two coherent RF signals generated from the custom-built RF signal generator [ 15 ] were fed to the same two RFPAs that were characterized with the supervision module. The amplified signals were connected to two wideband self-grounded bow-tie (SGBT) antennas [ 14 ] through two directional couplers (BDC0810-50/1500, BONN Elektronik, Holzkirchen, Germany) and the feed-through penetration panel of the MR scanner room.…”

Section: Methodsmentioning

confidence: 99%

“…The amplified signals were connected to two wideband self-grounded bow-tie (SGBT) antennas [ 14 ] through two directional couplers (BDC0810-50/1500, BONN Elektronik, Holzkirchen, Germany) and the feed-through penetration panel of the MR scanner room. The antennas were positioned opposite to each other and applied to a muscle-mimicking agarose phantom (length = 160 mm, width = 116 mm, height = 178 mm; ε r = 54.32, and σ = 0.25 S/m [ 15 ]). The phantom was placed in the isocenter of a 7.0 T human MR scanner (Magnetom, Siemens Healthineers, Erlangen, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…MR thermometry utilizing the proton-resonance-frequency-shift (PRFS) approach [ 36 , 37 ] (TR = 99 ms, TE1 = 2.73 ms, TE2 = 6.71 ms, and voxel size = 1.0 × 1.0 × 5.0 mm 3 [ 15 ]) at 297.2 MHz was conducted before and after each experiment. Vegetable oil was used as a reference to correct the magnetic field drifts [ 15 , 38 ]. Fiber optic temperature sensors (Neoptix, Quebec, QC, Canada) were used to validate the MRT results [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Vegetable oil was used as a reference to correct the magnetic field drifts [ 15 , 38 ]. Fiber optic temperature sensors (Neoptix, Quebec, QC, Canada) were used to validate the MRT results [ 15 ]. For benchmarking experimental data with numerical simulations, temperature simulations using the same frequency, power, and phase settings (400 MHz, 42.5 dBm, and ϕ = 0° for both channels at the feeding port of the SGBT antenna) were performed in CST Microwave Studio 2018 (Computer Simulation Technology GmbH, Darmstadt, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…A significant improvement of survival was reported for GBM patients receiving chemotherapy together with RF-induced HT [ 10 ]. Thermal magnetic resonance (ThermalMR) is an HT variant that integrates RF-induced heating [ 11 , 12 , 13 , 14 , 15 ], in vivo temperature mapping using MR thermometry (MRT) [ 16 , 17 , 18 , 19 ], anatomic and functional MR imaging (MRI), and the option for x-nuclei MRI in a single, multi-purpose RF applicator that permits supervised targeted temperature modulation.…”

Section: Introductionmentioning

confidence: 99%

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Multi-Channel RF Supervision Module for Thermal Magnetic Resonance Based Cancer Therapy

Han

Oberacker

Kuehne³

et al. 2021

Cancers

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Glioblastoma multiforme (GBM) is the most lethal and common brain tumor. Combining hyperthermia with chemotherapy and/or radiotherapy improves the survival of GBM patients. Thermal magnetic resonance (ThermalMR) is a hyperthermia variant that exploits radio frequency (RF)-induced heating to examine the role of temperature in biological systems and disease. The RF signals’ power and phase need to be supervised to manage the formation of the energy focal point, accurate thermal dose control, and safety. Patient position during treatment also needs to be monitored to ensure the efficacy of the treatment and avoid damages to healthy tissue. This work reports on a multi-channel RF signal supervision module that is capable of monitoring and regulating RF signals and detecting patient motion. System characterization was performed for a broad range of frequencies. Monte-Carlo simulations were performed to examine the impact of power and phase errors on hyperthermia performance. The supervision module’s utility was demonstrated in characterizing RF power amplifiers and being a key part of a feedback control loop regulating RF signals in heating experiments. Electromagnetic field simulations were conducted to calculate the impact of patient displacement during treatment. The supervision module was experimentally tested for detecting patient motion to a submillimeter level. To conclude, this work presents a cost-effective RF supervision module that is a key component for a hyperthermia hardware system and forms a technological basis for future ThermalMR applications.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multi-Channel RF Supervision Module for Thermal Magnetic Resonance Based Cancer Therapy

Han

Oberacker

Kuehne³

et al. 2021

Cancers

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32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T

Eigentler

Kuehne²,

Boehmert

et al. 2021

Magnetic Resonance in Med

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Purpose Design, implementation, evaluation, and application of a 32‐channel Self‐Grounded Bow‐Tie (SGBT) transceiver array for cardiac MR (CMR) at 7.0T. Methods The array consists of 32 compact SGBT building blocks. Transmission field (B1+) shimming and radiofrequency safety assessment were performed with numerical simulations and benchmarked against phantom experiments. In vivo B1+ efficiency mapping was conducted with actual flip angle imaging. The array’s applicability for accelerated high spatial resolution 2D FLASH CINE imaging of the heart was examined in a volunteer study (n = 7). Results B1+ shimming provided a uniform field distribution suitable for female and male subjects. Phantom studies demonstrated an excellent agreement between simulated and measured B1+ efficiency maps (7% mean difference). The SGBT array afforded a spatial resolution of (0.8 × 0.8 × 2.5) mm3 for 2D CINE FLASH which is by a factor of 12 superior to standardized cardiovascular MR (CMR) protocols. The density of the SGBT array supports 1D acceleration of up to R = 4 (mean signal‐to‐noise ratio (whole heart) ≥ 16.7, mean contrast‐to‐noise ratio ≥ 13.5) without impairing image quality significantly. Conclusion The compact SGBT building block facilitates a modular high‐density array that supports accelerated and high spatial resolution CMR at 7.0T. The array provides a technological basis for future clinical assessment of parallel transmission techniques.

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Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

Zhang

et al. 2022

Drug Delivery

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The field of biomedical research has recently been interested in nanoplatforms with various functionalities, such as cancer drug carriers and MRI and optical imaging, as well as thermal treatment, among other things. As a result of the present investigation, a unique multifunctional liposome (MFL) was established in this investigation. Using radiofrequency-induced imaging and drug release based on magnetic field impact, a dual drug delivery targeted with tumor multi-mechanism treatment was made more effective. The C60 (fullerene) surface was coated with iron nanocomposites to establish the proposed nanosystems, and PEGylation was used (Fe 3 O 4 -C60-PEG 2000 ). For fullerene radiofrequency-triggered drug release, thermosensitive DPPC liposomes with folate-DSPE-PEG 2000 enveloped the binary nanosystems and doxorubicin (DOX). The in vitro cytotoxicity of the nanocomposites was confirmed by the liver metastasis in HT-29 colon cancer cells using radiofrequency. The flow cytometry analysis confirmed the apoptosis cell death mechanism. The thermal treatment combined chemotherapeutic MFL nano framework transformed radiofrequency radiation from thermoresponsive liposomes, which was noticed both in vivo and in vitro . Due to their superior active tumor targeting and magnetic targeting characteristics, the MFL could also selectively destroy cancerous liver cells in highly co-localized targets.

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Design, Implementation, Evaluation and Application of a 32-Channel Radio Frequency Signal Generator for Thermal Magnetic Resonance Based Anti-Cancer Treatment

Cited by 9 publications

References 55 publications

Multi-Channel RF Supervision Module for Thermal Magnetic Resonance Based Cancer Therapy

Multi-Channel RF Supervision Module for Thermal Magnetic Resonance Based Cancer Therapy

32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T

Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

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