Design, Formulation, Optimization and In-vitro Evaluation of Colon-targeted Tablet Utilizing Polymer Isolated from Artocarpus heterophyllus

Abstract

Objective: The objective of the present study is to formulate, optimize, and evaluate the colon-targeted oral Tablet by utilizing the polymer obtained from Artocarpus heterophyllus. Ibuprofen was used as a model drug in the study. Methods: The Polymer was extracted from the fresh fruits of Artocarpus heterophyllus and subjected to identification and characterization. The formula of the Tablet was optimized using 3 factors 3 levels Box-Behnken design (Design Expert Software). The colon-targeted Tablets were then formulated and coated with pH-dependent polymer to avoid release in the upper gastrointestinal tract. Results: Pre-compression and post-compression characteristics of the Tablet were studied which were within the standard limits.