Design, Formulation, Evaluation and Statistical Optimization of Coated Floating Pulsatile Tablets for Modified Chronopharmacotherapy of Rheumatoid Arthritis
pasam jyothirmayi
Abstract:Objective
The main aim of designing Coated Floating Pulsatile Tablets (CFPT) of Tramadol hcl for statistical optimization and to perform in vitro and in vivo buoyancy evaluation for modified chronopharmacotherapy of rheumatoid arthritis.
Methods
The formulation was designed with the immediate core covered with a compression coat followed by the upper buoyant layer. Best formulations of Immediate burst release core tablets were compression coated with polymer HPMC K15M, Ispaghula gum (IG), and Tamarindus gum … Show more
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