Design Formulation and in vitro Evaluation of Gastroretentive Microspheres of Selegiline Hydrochloride for Parkinson’s Disease by Design Expert
Raghavarapu Prasanthi,
Balusu Haarika,
Subramanian Selvamuthukumar
Abstract:Introduction: Selegiline hydrochloride is primarily used to treat Parkinson's disease. Selegiline hydrochloride mucoadhesive microspheres were prepared to improve the bioavailability of the drug and its appropriate therapeutic performance. Materials and Methods: The ionic gelation process was used to formulate the gastroretentive mucoadhesive microspheres using different polymers such as gum kondagogu (150 to 450 mg), karaya gum (10 to 70 mg), and carbopol 940P (150 to 450 mg) of different concentrations in pr… Show more
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