Design, Formulation and Evaluation of Piroxicam Capsules Prepared by Solid Dispersion Technique

Swidan, Shady

doi:10.9734/bjpr/2013/2534

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…CCD is also known as Box-Wilson design. The "composite design" contains embedded(2k) FD or (2k-r ) FFD, augmented with a group of star points (2R) and a central point 4,5 . A face centred cube design(FCCD) result when both factorial and star points in a CCD possess same positive and negative distance from centre.…”

Section: Methodsmentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:The objective of present study was to preclude of poor dissolution of relatively water insoluble and poorly permeable drug by formulating gastroretentive floating tablet using solid dispersion (SD) of the drug. It aimed to increase the drug solubility and gastric retention of the drug for better absorption profile. Cefpodoxime proxetil is an orally absorbed third generation cephalosporin antibiotic. The oral bioavailability and biological half life is 50% and 2.09 to 2.84 hrs respectively. Two grades of Polyethylene glycol (PEG); PEG 4000 and PEG 6000 in combination were used for the formulation of solid dispersion. Formulation batch SD8 was found to be optimized according to the face centred cube design (FCCD). Solubility and the drug release from batch SD8 was maximum in 0.1N HCL, 18.93mg/ml and 94.66% respectively as compared to physical mixtures (PM) and pure drug. The physical mixture having same carrier ratio (PEG 4000+PEG 6000) that is PM8 has solubility and drug release 13.93mg/ml and 76.34% respectively. The study showed that solubility and drug release has linear relationship with PEG concentration. The optimized batch of the SD was further used for the formulation of the gastroretentive floating tablets by using HPMC K15 M as the hydrophilic polymer and sodium bicarbonate as gas generating agent. The gastroretentive floating tablets was formulated by direct compression method and tested for various physicochemical parameters for tablets like tablet weight variation, thickness, hardness, friability, content uniformity, in vitro buoyancy studies, swelling index and in vitro drug release.

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Section: Methodsmentioning

confidence: 99%

Untitled

2016

IJPSR

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“…The concentration of this solution was (10 µg /ml). The solution was assayed spectrophotometrically at 353 nm for calculating the PRXM content [29]. The polymers did not show any interference with the absorbance of the drug at this wave length [30].…”

Section: The Drug Contentmentioning

confidence: 99%

Design, Formulation and Evaluation of Piroxicam Capsules Prepared by Solid Dispersion Technique

Swidan

2013

BJPR

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Objective: To improve the dissolution of poorly soluble Piroxicam (PRXM) by solid dispersion technique using water soluble carriers with or without the addition of sodium lauryl sulphate (SLS) as surfactant. Methods and Materials: Solid dispersions of Piroxicam were prepared using different polymers such as polyethylene glycol (PEG 4000 and PEG 6000) polyvinylpyrrolidone (PVP K30 and PVP K90) without or with addition of 2% of (SLS). Solid dispersions were formulated in drug polymer ratios 1:1, 1:2, and 1:4, each ratio without or with 2% SLS using solvent evaporation method. The prepared formulae were assayed for drug content, production yield and stability properties. Dissolution profiles were done in phosphate buffer pH 7.4 and the in vitro release was evaluated according to the % released after 20, 30, 45 and 60 minutes. An accelerated stability study was done over 3 months at 40 o and 60ºC and with relative humidity (RH) 75%. Results and Discussion: All of the formulated solid dispersions displayed better dissolution profiles as compared to the pure drug. Formulae containing 2% SLS displayed

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“…Research conducted by Chen et al, make modifications with the solid dispersion system against ibuprofen-urea by the melting method [6]. In another study, a piroxicam-PEG 4000 solid dispersion system was made using the solvent evaporation method [7]. The spray drying method is used in making celecoxib solid dispersions with isomalt polymers and PVP-K30 [8].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review: The Enhancement of Anti-Inflammation Activity of Non Steroidal Anti-Inflammatory Drug (Nsaid) by Solid Dispersion Modifications

2021

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Objective: NSAIDs are very hydrophobic drugs and have low solubility. This causes the bioavailability of NSAIDs to be low in the body thus affect its anti-inflammatory activity. There has been some primary research proven that solid dispersion can increase the solubility and anti-inflammatory activity of NSAIDs. Moreover, there are not researches explaining the effect of a solid dispersion system on the anti-inflammatory activity of NSAIDs. Therefore, it is necessary to conduct a review to assess the effect of the solid dispersion system on the solubility and anti-inflammatory activity of NSAIDs systematically. Methods: This was systematic review research, where the data were originated from PubMed and Science Direct with the keywords ‘NSAID’, ‘solid dispersion’, and ‘drug effect’. The inclusion criteria formulated were English-language papers, published in 2010–2020, and primary research that conducted in vivo anti-inflammatory testing. The appropriate papers by the inclusion criteria were assessed its quality by the SYRCLE’s tool. Data was analyzed narratively. Results: The results were eight papers under the inclusion criteria. As a whole is known modification of solid dispersion can increase the dissolution profile of NSAIDs. This is because the polymer used can increase the wetting of drug particles, thereby being able to increase the solubility of NSAIDs. Conclusion: The anti-inflammatory activity of NSAIDs by solid dispersion systems are increases compared to NSAIDs without solid dispersions.

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Design, Formulation and Evaluation of Piroxicam Capsules Prepared by Solid Dispersion Technique

Cited by 6 publications

References 48 publications

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Design, Formulation and Evaluation of Piroxicam Capsules Prepared by Solid Dispersion Technique

Systematic Review: The Enhancement of Anti-Inflammation Activity of Non Steroidal Anti-Inflammatory Drug (Nsaid) by Solid Dispersion Modifications

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