Design, fabrication and characterization of nanocaged 12CaO·7Al2O3:Tb3+ photostimulable phosphor for high-quality X-ray imaging

Li, Shengnan; Liu, Yuxue; Yan, Duanting; Zhu, Hancheng; Yang, Jian; Zhang, Meng; Xu, Changshan; Ma, Li; Wang, Xiaojun

doi:10.1016/j.matdes.2017.08.027

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…Recently, a series of new nanoparticle formulations have been proposed for X-PDT. These include Ce 0.85 Tb 0.15 F 3 nanoparticles in a CTAB chlorin e6 shell, 12CaOÁ7Al 2 O 3 :Tb 3+ nanocages, (Y 1-x Pr x ) 3 Al 5 O 12 nanocrystals, and GdVO 4 :Eu 3+ nanoparticles conjugated to methylene blue (Cooper, Capobianco, & Seuntjens, 2018;Jung et al, 2014;Li et al, 2017;Losytskyy et al, 2016Losytskyy et al, , 2017Song et al, 2018;Yefimova et al, 2017). However, none of these particles have yet moved beyond energetics analysis.…”

Section: Origins and Design Considerationsmentioning

confidence: 99%

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Cline

Delahunty

Xie

2018

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) has emerged as an attractive option for cancer treatment. However, conventional PDT is activated by light that has poor tissue penetration depths, limiting its applicability in the clinic. Recently the idea of using X-ray sources to activate PDT and overcome the shallow penetration issue has garnered significant interest. This can be achieved by external beam irradiation and using a nanoparticle scintillator as transducer. Alternatively, research on exploiting Cherenkov radiation from radioisotopes to activate PDT has also begun to flourish. In either approach, the most auspicious success is achieved using nanoparticles as either a scintillator or a photosensitizer to mediate energy transfer and radical production. Both X-ray induced PDT (X-PDT) and Cherenkov radiation PDT (CR-PDT) contain a significant radiation therapy (RT) component and are essentially PDT and RT combination. Unlike the conventional combination, however, in X-PDT and CR-PDT, one energy source simultaneously activates both processes, making the combination always in synchronism and the synergy potential maximized. While still in early stage of development, X-PDT and CR-PDT address important issues in the clinic and hold great potential in translation. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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Section: Origins and Design Considerationsmentioning

confidence: 99%

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Cline

Delahunty

Xie

2018

WIREs Nanomed Nanobiotechnol

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“…Among these applications, beam diagnostic, ,− microradiography, ,, or electron microscopy can be mentioned. There are materials with very slow decays, so-called storage phosphors, applicable in X-ray imaging . On the other hand, we pursue the shorest possible image acquisition time and fastest decay time in this article.…”

Section: Introductionmentioning

confidence: 99%

“…There are materials with very slow decays, so-called storage phosphors, applicable in X-ray imaging. 92 On the other hand, we pursue the shorest possible image acquisition time and fastest decay time in this article.…”

Section: Introductionmentioning

confidence: 99%

Tailoring and Optimization of LuAG:Ce Epitaxial Film Scintillation Properties by Mg Co-Doping

Průša

Kučera

Babin

et al. 2018

Crystal Growth & Design

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Six Mg co-doped Lu 3 Al 5 O 12 :Ce scintillating films were prepared by a liquid phase epitaxy method, having Mg concentration of 0−3000 ppm. The following luminescence and scintillation characteristics and their dependence on Mg concentration were studied: photoluminescence emission and excitation spectra, radioluminescence spectra, photoluminescence and scintillation decay curves, light yield, energy resolution, and afterglow. Light yield increases with Mg concentration until 700 ppm and becomes 15−20% higher than in the Mg-free sample. Further increase of Mg concentration leads to light yield decrease. Scintillation decay is getting faster with an increasing Mg concentration and the afterglow is significantly reduced. The results are compared to ceramics and crystals of very similar compositions.

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“…6 After all, the aforementioned technique belongs to one kind of X-ray computed radiography (CR) systems, and the imaging plate can be reused only after heating or photostimulation. 14,15 Compared to the CR system, the digital radiography system based on the radioluminescence (RL) upon X-ray excitation can realize speedy and efficient real-time imaging.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Ou et al have developed a flexible detector fabricated by embedding NaLuF 4 :Tb@NaLuF 4 nanoscintillators into a polydimethysiloxane substrate and realized high-resolution 3D X-ray luminescence extension imaging combining with afterglow luminescence and graphical simulations . After all, the aforementioned technique belongs to one kind of X-ray computed radiography (CR) systems, and the imaging plate can be reused only after heating or photostimulation. , Compared to the CR system, the digital radiography system based on the radioluminescence (RL) upon X-ray excitation can realize speedy and efficient real-time imaging.…”

Section: Introductionmentioning

confidence: 99%

Afterglow-Suppressed Lu₂O₃:Eu³⁺ Nanoscintillators for High-Resolution and Dynamic Digital Radiographic Imaging

et al. 2022

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Lu 2(1−x) Eu 2x O 3 nanoscintillators (x = 0.005, 0.01, 0.03, 0.05, 0.07, and 0.10) with red emission were synthesized by a coprecipitation method. It is found that their photo-and radioluminescence intensities increase with increasing Eu 3+ concentration until x = 0.05. According to their concentrationdependent luminescence intensity ratios (I 610 (C 2 )/I 582 (S 6 )), the existing energy transfer from Eu 3+ (S 6 ) (occupying S 6 sites) to Eu 3+ (C 2 ) (occupying C 2 sites) can be confirmed. Based on the spectral data and density functional theory (DFT) calculations, the origin of Lu 2 O 3 :Eu 3+ persistent luminescence at low concentration might be related to the tunneling processes between Eu 3+ (occupying C 2 and S 6 sites) and oxygen interstitials (O i × ). After dispersing afterglow-suppressed Lu 2 O 3 :Eu 3+ nanoscintillators into polymethyl methacrylate (PMMA) polymer-acetone solution, flexible PMMA-Lu 2 O 3 :Eu 3+ composite films with high thermal stability and radiation resistance were fabricated by a doctor blade method. As the flexible composite film was used as an imaging plate, static X-ray images with high spatial resolution (5.5 lp/mm) under an extremely low dose of ∼1.1 μGy air can be acquired. When a watch with a moving second hand was used as an object, the dynamic X-ray imaging can be realized under a dose rate of 55 μGy air •s −1 . Our results demonstrate that Lu 2 O 3 :Eu 3+ nanoscintillators can be regarded as candidate materials for dynamic digital radiographic imaging.

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Design, fabrication and characterization of nanocaged 12CaO·7Al2O3:Tb3+ photostimulable phosphor for high-quality X-ray imaging

Cited by 12 publications

References 45 publications

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Tailoring and Optimization of LuAG:Ce Epitaxial Film Scintillation Properties by Mg Co-Doping

Afterglow-Suppressed Lu₂O₃:Eu³⁺ Nanoscintillators for High-Resolution and Dynamic Digital Radiographic Imaging

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Design, fabrication and characterization of nanocaged 12CaO·7Al2O3:Tb3+ photostimulable phosphor for high-quality X-ray imaging

Cited by 12 publications

References 45 publications

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Tailoring and Optimization of LuAG:Ce Epitaxial Film Scintillation Properties by Mg Co-Doping

Afterglow-Suppressed Lu2O3:Eu3+ Nanoscintillators for High-Resolution and Dynamic Digital Radiographic Imaging

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Product

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Afterglow-Suppressed Lu₂O₃:Eu³⁺ Nanoscintillators for High-Resolution and Dynamic Digital Radiographic Imaging