Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art

Notario-Pérez, Fernando; Cazorla-Luna, Raúl; Martín-Illana, Araceli; Galante, Joana; Ruíz-Caro, Roberto; Neves, José das; Veiga, María-Dolores

doi:10.1016/j.jconrel.2020.08.032

Cited by 40 publications

(33 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymeric films are another area explored, which undoubtedly has advanced significantly, to deliver pharmaceuticals in the treatment of vaginal ailments. The advantages of gels and solid pharmaceutical dosage forms are amalgamated in the film dosage form where versatility of polymers provides the platform to develop films of desired characteristics [89]. Application of these films has been extended to evaluate against vaginal bacterial [90], viral [89,91] and fungal infections [92].…”

Section: Vaginal Filmsmentioning

confidence: 99%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

View full text Add to dashboard Cite

An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

show abstract

Section: Vaginal Filmsmentioning

confidence: 99%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The electrospun bers can be applied in biomedicine, pharmacy, food, water treatment, air purication, energy electronics and information engineering. [12][13][14][15][16][17][18][19][20][21] The electrospun bers can be fabricated using natural polymer or synthetic polymer as the main substrate materials and the appropriate solvents based on these different elds. The preparation process shows a greater deal of autonomy and plasticity.…”

Section: Introductionmentioning

confidence: 99%

Sabina chinensis leaf extracted and in situ incorporated polycaprolactone/polyvinylpyrrolidone electrospun microfibers for antibacterial application

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Films are one of the forms of wound dressing that predominate commercially due to their mechanical resistance, ease of application, versatility in sizes, and because they offer uniform protection. Films differ from membranes in thickness; films are usually about 100 µm thick or less (6). Films can be occlusive (seal the wound) or semiocclusive (with microscopic pores to allow the transmission of gases); these can include a single layer or different layers of different compositions.…”

Section: Introductionmentioning

confidence: 99%

Development of films from natural sources for infections during wound healing

Leyva-Gómez

González‐Torres

Alcalá-Alcalá

et al. 2021

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

The skin is the largest organ in the human body, and due to its barrier function, it is susceptible to multiple injuries. The appearance of infections during the wound healing process is a complication that represents a formidable hospital challenge. The presence of opportunistic bacteria with sophisticated resistance mechanisms is difficult to eradicate and compromises patients' lives. Therefore, the search for new efficacious treatments from natural sources that prevent and counteract infections, in addition to promoting the healing process, has increased in recent years. In this respect, films with the capability to protect wounds and release drugs are the presentation that predominates commercially in the hospital environment. Those films can offer several mechanical advantages such as physical protection to prevent opportunistic bacteria's entry, regulation of gas exchange, and capture of exudate through a swelling process. Wound dressings are generally curative materials easily adaptable to different anatomical regions, with high strength and elasticity, and some are even bioabsorbable. Additionally, the components of the films can actively participate in promoting the healing process. Even more, the film can be made up of carriers with other active participants to prevent and eradicate infections. Therefore, the extensive versatility, practicality, and usefulness of films from natural sources to address infectious processes during wound healing are relevant and recurrent themes. This work presents an analysis of the state-of-the-art of films with natural products focused on preventing and eradicating infections in wound healing.

show abstract

Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art

Cited by 40 publications

References 135 publications

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Sabina chinensis leaf extracted and in situ incorporated polycaprolactone/polyvinylpyrrolidone electrospun microfibers for antibacterial application

Development of films from natural sources for infections during wound healing

Contact Info

Product

Resources

About