Design, Development of Pyrazole‐Linked Spirocyclopropyl Oxindole‐Carboxamides as Potential Cytotoxic Agents and Type III Allosteric VEGFR‐2 Inhibitors
Durgesh Gurukkala Valapil,
Geetanjali Devabattula,
Akash P. Sakla
et al.
Abstract:Tumor progression depends on angiogenesis, which is stimulated by growth factors like VEGF, targeting VEGFR kinase with small molecules is an effective anti‐angiogenic therapeutic approach. Sunitinib was rationally modified to spirocyclopropyloxindoline carboxamides and their in vitro cytotoxic profiling were evaluated. The molecular modelling studies enabled the screening of designed analogues and identified possible interactions within the type III allosteric inhibitor binding site of VEGFR‐2. The biological… Show more
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