Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi-Solve

Liu, Hongbin; Sama, Gopal R.; Robinson, Andrea J.; Mountford, Simon J.; Thompson, Phillip E.; Rodda, Andrew Edwin; Forsythe, John S.; Mornane, Patrick J; Pasic, Paul; Thissen, Helmut; Byrne, Melissa; Kaye, D.; Dear, Anthony E.

doi:10.1007/s13239-021-00525-y

Cited by 1 publication

(2 citation statements)

References 24 publications

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“…Standard Armada 35 PABA catheters, 4.0–5.0 mm diameter and 50.0–70.0 mm in length (Abbott Australasia Pty Ltd) and 0.035in, 150 cm GW (Boston Scientific, Starter™) were used together with customised 500 µm core fibre-optic, Model RD 30 with SMA 905 connector (Med light S.A, Switzerland), connected to a Silver-LED-365nmUV 100mW portable light source (Prizmatix, Israel) as previously described [ 1 ]. The Model RD 30 fibre-optic has a unique distal diffuser portion permitting uniform, radial transmission of UV365nm light along its entire length within the inflated angioplasty balloon [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

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Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device

Sangeetha Menon,

Subasic de Azevedo,

Choong

et al. 2023

Cardiovasc Eng Tech

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Purpose The Lumi-Solve photo-angioplasty drug eluting balloon catheter (DEBc) may afford safety advantages over current DEBc. Lumi-Solve utilises the guidewire (GW) port and lumen to deliver fibre-optic UV365nm light to the angioplasty balloon which may be problematic. We explore and evaluate alternative Lumi-Solve design options to circumvent fibre-optic use of the GW port and lumen which may enhance efficacy and clinical utility. Methods Effects of guidewire shadowing (GWS) on visible and UV365nm light transmission were evaluated and modelled in-silico. To evaluate the effect of a dedicated intra-balloon fibre-optic port, modified angioplasty balloons and sections of translucent polyethylene terephthalate (PET) GW port tubing were utilised. Investigation of the effect of GWS on chemical and biological photo-activation of balloon surface drug was performed utilising LCMS analysis and inhibition of histone deacetylase activity (HDACi) was measured in human umbilical vein endothelial cells (HUVEC). Results Parallel fibre-optic and GW port configurations generated a GWS of approximately 18.0% of the evaluable balloon surface area and attenuated both visible and UV light intensity by 20.0–25.0% and reduced chemical photo-activation of balloon surface drug and HDACi by at least 40–45%. Alternative fibre-optic port configurations including a spiral design significantly mitigated GWS effects on UV light transmission. Conclusions To avoid use of the GW port and its associated complications a dedicated third port and lumen for the Lumi-Solve fibre-optic may be required. To maximize balloon surface chemical and biological photo-activation, non-parallel, intra-balloon, fibre-optic lumen trajectories, including a spiral design may be useful.

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Section: Methodsmentioning

confidence: 99%

“…We have recently described a novel drug-eluting, photo-activated balloon angioplasty device Lumi-Solve, for the management of post-angioplasty neointimal hyperplasia [ 1 ].…”

Section: Introductionmentioning

confidence: 99%