The CCD remains the preeminent visible and ultra-violet wavelength image sensor in space-science, Earth and planetary remote sensing. However, the design of space-qualified CCD readout electronics is a significant challenge with requirements for low-volume, low-mass, low-power, high-reliability and sufficient tolerance to the effects of space radiation. Appropriate space-qualified components that are acceptable to international space agencies are frequently unavailable and up-screened commercial components may not meet project requirements. We have adopted an alternative approach of designing and space-qualifying a series of both low-and high-voltage mixed-signal ASICs to meet these requirements. In this paper we describe our latest ASIC developments including two entirely new high-voltage devices, and our work to upgrade the performance of our earlier devices after many years of successful flight heritage. A challenging sub-system of any CCD camera is the video processing and digitisation electronics. Our first CCD video ASIC was developed in late 1999 and now has considerable flight heritage in cameras on NASA's Solar Terrestrial Relations Observatory and Solar Dynamics Observatory. In this paper, we describe our more recent developments to improve its performance and radiation tolerance to single event latchup. Alongside the CCD video processing electronics, the circuitry to generate a CCD's DC bias voltages and drive clocks constitute a significant proportion of a typical CCD camera and present a number of design challenges, exacerbated by the limited range of space-qualified components. To resolve these issues, we have embarked on a programme to develop two high-voltage CCD drive ASICs. Implemented in a 0.35 μm, 50 V tolerant CMOS process, they combine low-voltage 3.3 V transistors that are used within interface logic, voltage reference and digital-to-analogue circuitry, and also high-voltage 50 V diffused MOSFET transistors that can drive a CCD's DC bias and clock electrodes directly. Our DC bias voltage generator ASIC provides 24 independent and programmable 0-32 V bias outputs. Each channel consists of a 10-bit DAC and a high-voltage output buffer to provide current drive of up to 20 mA into loads of 10 μF, and is current-limited for short circuit protection. An on-board telemetry system featuring a 12-bit ADC and programmable gain buffer allows measurement of the outputs from the bias generators as well as up to 32 single-ended and 4 differential external voltages. One ASIC can drive one or more CCDs directly and replaces an entire PCB of discrete electronics in our current camera electronic systems. Our clock driver ASIC provides 6 independent and programmable drivers with sufficient current drive for even a large-format CCD's capacitive electrodes. Each driver allows the clock rise-time, fall-time, clock-low and clock-high voltage levels to be programmed independently. It allows the one design to be configured and optimised to drive a CCD's typically 0.1-2 MHz serial readout register clocks or 10-100 ...