Design, Development and in vitro Assessment of Flurbiprofen Microemulsion Gel for Transdermal Drug Delivery

Abstract

The aim of current research is to develop flurbiprofen microemulsion gel for transdermal delivery. To prepare a microemulsion oil, surfactant and co-surfactant selection is one of the important criteria. Selected to prepare different ratios of oil and surfactant mixture using ternary phase diagram. Based on results of physicochemical properties, we have optimized one formulation. The optimized microemulsion formulation incorporated into carbopol P 934 gel base. The In vitro diffusion of drug release shown maximum (98.6% in 12hrs) for prepared microemulsion gel than marketed gel (60.5% in 16 hrs).