Design, development and<i>in-vitro</i>evaluation of diclofenac taste-masked orodispersible tablet formulations

Guhmann, Marie; Preis, Maren; Gerber, Frédéric; Pöllinger, Norbert; Breitkreutz, Jörg

doi:10.3109/03639045.2014.884122

Cited by 40 publications

(28 citation statements)

References 26 publications

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“…Researchers working on the development of pharmaceutical formulations consider the use of artificial sensing systems as a supplementation to conventionally used methods. Recently, a commercial taste sensing system (TS-5000Z) was used to differentiate novel oral dosage forms (i.e., orally disintegrating tablets (ODTs)) containing diclofenac [45] and lyophilisates containing cetirizine hydrochloride [46]. A laboratory prototype of an electronic tongue was able to distinguish microparticles, lyophilisates, and ODTs containing dihydrochloride cetirizine [47].…”

Section: Introductionmentioning

confidence: 99%

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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Electronic tongue systems equipped with cross-sensitive potentiometric sensors have been applied to pharmaceutical analysis, due to the possibility of various applications and developing new formulations. Many studies already proved the complementarity between the electronic tongue and classical analysis such as dissolution tests indicated by Pharmacopeias. However, as a new approach to study pharmaceuticals, electronic tongues lack strict testing protocols and specification limits; therefore, their results can be improperly interpreted and inconsistent with the reference studies. Therefore, all aspects of the development, measurement conditions, data analysis, and interpretation of electronic tongue results were discussed in this overview. The critical evaluation of the effectiveness and reliability of constructed devices may be helpful for a better understanding of electronic tongue systems development and for providing strict testing protocols.

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Section: Introductionmentioning

confidence: 99%

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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“…ODTs disintegrate in the oral cavity within seconds and are washed out with saliva without the need of liquid 3 . These tablets are also suitable for those who are travelling and do not have easy access to water, mentally ill, bedridden and patients with persistent nausea [4][5][6] . It is also useful for the patients, where the underlying disease disrupts swallowing ability (e.g.…”

Section: Introductionmentioning

confidence: 99%

Formulation and development of orodispersible sustained release tablet of domperidone

Patil

Tiwari

Repka

et al. 2015

Drug Development and Industrial Pharmacy

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Abstract:Commercially available domperidone orodispersible tablets (ODT) are intended for immediate release of the drug but none of them have been formulated for sustained action. The aim of the present research work was to develop and evaluate orodispersible sustained release tablet (ODT-SR) of domperidone, which has the convenience of ODT and benefits of controlled release product combined in one. The technology comprised of developing sustained release microspheres (MS) of domperidone, followed by direct compression of MS along with suitable excipients to yield ODT-SR which rapidly disperses within 30 seconds and yet the dispersed MS maintain their integrity to have a sustained drug release. The particle size of the MS was optimized to be less than 200 μm to avoid the grittiness in the mouth. The DSC thermograms of MS showed the absence of drug-polymer interaction within the microparticles, while SEM confirmed their spherical shape and porous nature. Angle of repose, compressibility and Hausner's ratio of the blend for compression showed good flowability and high percent compressibility. The optimised ODT-SR showed disintegration time of 21 seconds and matrix controlled drug release for 9 h. Invivo pharmacokinetic studies in Wistar rats showed that the ODT-SR had a prolonged MRT of 11.16 h as compared 3.86 h of conventional tablet. The developed technology is easily scalable and holds potential for commercial exploitation.

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“…For example, Eudragit E PO is insoluble in neutral and basic pH but soluble in acidic pH (65). In a try to overcome this, citric acid was used as both pH-modifying agent and taste-masking agent with Eudragit E PO (66). In addition, it was also found that directly coating irregular-shaped drug particles with polymers was promising in achieving a wide size distribution for further application in ODT platforms.…”

Section: Formation Of Core-shell Structures Via Coatingmentioning

confidence: 99%

“…In addition, it was also found that directly coating irregular-shaped drug particles with polymers was promising in achieving a wide size distribution for further application in ODT platforms. Moreover, when prepared by the fluidized bed process, the coated microgranules were much more effectively taste-masked than coated drug crystals (65,66). Finally, although coating with polymers might impair palatability, it can be improved by coating an outer layer containing flavors like mannitol (58).…”

Section: Formation Of Core-shell Structures Via Coatingmentioning

confidence: 99%

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

et al. 2019

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Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (including fast-release systems, sustained-release systems, and targeted-release systems). However, there are certain problems in the practical application, such as bitter taste and coating damage. Combining with some polymer or lipid materials to form core-shell or embedded structures is considered as the key to taste masking. And, using cushioning agents is proven to be effective in preserving the integrity of the functional coating film of multiparticulates during tableting. To sum up, this review, from a particle engineering point, expounds the influence of different factors on the functionality of particles and offers some useful comments and suggestions for industry personnel.

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Design, development andin-vitroevaluation of diclofenac taste-masked orodispersible tablet formulations

Abstract: A novel palatable and fast acting diclofenac ODT formulation was successfully developed. Formulation design, development and in-vitro evaluation used in this study may serve as rational approach for manufacturing taste-masked orodispersible dosage forms.

Cited by 40 publications

References 26 publications

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Formulation and development of orodispersible sustained release tablet of domperidone

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

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