Design, construction and performance evaluation of the target tissue thickness measurement system in intraoperative radiotherapy for breast cancer

Yazdani, Mehrdad; Setayeshi, Saeed; Arabalibeik, Hossein; Akbari, Mohammad Esmaeil

doi:10.1016/j.nima.2016.12.065

Cited by 4 publications

(8 citation statements)

References 27 publications

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“…Herskind's Radiobiological Models (18) attempt to explain why the distribution of kV dose can provide comparable treatment to electrons. TARGIT's final results (20)(21)(22) and perchance additional studies can also help in proving the equivalence.…”

Section: Pre-planned Dose In Iort Uncertainties and Deviationsmentioning

confidence: 97%

“…For this reason, it is necessary to have documentation and comprehensive reporting. This record should include geometry and anatomical relations of the treatment site, shielded areas, if any, and applicator definition such as shape, size, position, angle, and beam energy (20,21). In short, we are at the beginning of the journey in IORT treatment planning development.…”

Section: Treatment Planning Systems For Iortmentioning

confidence: 99%

“…Having studied 1,822 patients in Italy from 1999 to 2008, Veronesi again indicated in 2010 that ELIOT appears to be a promising feature in early breast cancer treated with breast-conserving surgery, which reduces normal tissue exposure to radiation and shortens the radiation course from six weeks to one session (21). According to the ELIOT trial findings, a single dose of IOERT is a way to avoid mastectomy, decrease the risk of possible toxicity, improve the quality of life, and increase the patient's treatment accessibility (57).…”

Section: Eliot Clinical Trialmentioning

confidence: 99%

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Intra-Operative Radiotherapy in Breast Cancer Treatment: A Literature Review

Yazdi¹,

Setayeshi²

2019

Iran Red Crescent Med J

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Context: The process of direct radiation to the tumor or tumor residue during surgery known as Intraoperative Radiation Therapy (IORT) is a new promising technique in the treatment of different cancers. For a detailed review of IORT application and effectiveness in breast cancer, we conducted a review of the present literature in the field. Evidence Acquisition: In this study, the most important technologies for IORT were identified through a comprehensive study. Relevant, critical, and highly cited articles and studies were selected based on experts' opinions. Data were summarized in sections of technology and physics, protocols, and treatment outcomes. Results: Electron beam and low-energy X-ray technologies were explained, and the physique of IORT was discussed. Due to the uncertainties of this modality and geometric complexities of post-excision treatment site, specialized treatment planning systems for IORT are necessary. In breast cancer treatment, regardless of the employed technology, IORT is applied with two main protocols: Partial Breast Irradiation and Intraoperative Boost Irradiation, each with their own advantages and disadvantages. Conclusions: Despite the controversies in acceptance and effectiveness of IORT, this technique seems to be promising for increased survival of breast cancer patients.

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Section: Pre-planned Dose In Iort Uncertainties and Deviationsmentioning

confidence: 97%

Section: Treatment Planning Systems For Iortmentioning

confidence: 99%

Section: Eliot Clinical Trialmentioning

confidence: 99%

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Intra-Operative Radiotherapy in Breast Cancer Treatment: A Literature Review

Yazdi¹,

Setayeshi²

2019

Iran Red Crescent Med J

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“…Intraoperative Radiation Therapy (IORT) is a specific method that may transfer sufficient and monotonous high-dose radiation to the tumor bed during surgery [ 1 - 4 ]. This treatment method decreases local recurrence risk, and healthy tissue receives a minor dose due to its localized radiation [ 5 , 6 ]. The physician’s serious effort is impressively sending an intensive dose to the desired tissue while decreasing damage to healthy tissues surrounding the region of interest [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the thickness of target tissue with unacceptable is measured using a needle [ 33 ]; intraoperative ultrasound is another method to specify the thickness [ 2 , 15 , 23 ]. A novel electronic board was designed to determine the thickness of target tissue based on measuring the electron flux at the board with an accuracy better than the others [ 5 ]. This study aimed to investigate a method to compute the thickness of target tissue in the IORT routine.…”

Section: Introductionmentioning

confidence: 99%

A Novel Treatment Planning Design for Intraoperative Electron Radiation Therapy (IOERT) using an Electronic Board

2022

J Biomed Phys Eng

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Background: Intraoperative Irradiation Therapy (IORT) refers to the delivery of radiation during surgery and needs the computed-thickness of the target as one of the most significant factors.Objective: This paper aimed to compute target thickness and design a radiation pattern distributing the irradiation uniformly throughout the target. Material and Methods:The Monte Carlo code was used to simulate the experimental setup in this simulation study. The electron flux variations on an electronic board's metallic layer were studied for different thicknesses of the target tissue and validated with experimental data of the electronic board.Results: Based on the electron number for different Poly Methyl Methacrylate (PMMA) phantom thicknesses at various energies, 6 MeV electrons are suitable to determine the target thickness. Uniformity in radiation and corresponding time for each target were investigated. The iso-dose and percentage depth dose curves show that higher energies are suitable for treatment and distribute uniform radiation throughout the target. Increasing the phantom thickness leads to rising radiation time based on the radiation time corresponding to these energies. The tissue thickness of each section is determined, and the radiation time is managed by scanning the target. Conclusion:Calculation of the thickness of the remaining tissue and irradiation time are needed after incomplete tumor removal in IORT for various remaining tissues. The patients should be protected from overexposure to uniform irradiation of tissues since the radiation dose is prescribed and checked by an oncologist.

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