Design considerations for surface plasmon resonance-based fiber-optic detection of human blood group

Abstract

A fiber-optic surface plasmon resonance (SPR) sensor for the detection of human blood groups is proposed. Previous experimental results describing the wavelength-dependent refractive index variation of multiple samples of different blood groups are considered for theoretical calculations. The spectral interrogation method, along with silica fiber and silver layer, is considered. The sensor's performance is closely analyzed in terms of shift in SPR wavelength and SPR curve width in order to optimize the design parameters for a reliable and accurate blood-group identifier. The sensor design parameters include silver layer thickness, fiber core diameter, sensing region length, and temperature variation. The results are explained in terms of light coupling and plasmon resonance condition. The proposed sensing probe is able to provide high sensitivity and accuracy of blood-group detection, thereby opening an easy and reliable window for medical applications.

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“…When the environmental refractive index increases from 1.1 to 1.5 with a step length of 0.1, a significant red shift of the two peaks can be observed. Sensing capability of sensor is generally estimated by the sensitivity (S) and figure of merit (FOM) Due to the refractive index sensing characteristics of the dual-band MMA absorber, it can also be used to detect DNA [43], human blood group [44], cancerous cells [45], glucose concentration [46]. Adding different amounts of glucose to water can obtain glucose solutions with different refractive indices.…”

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“…An optimum film thickness and length can be selected to achieve the highest response in the reflectance spectrum [46]. The performance of the sensor is improved as the ratio of the sensing length to core diameter is decreased [112,113]. The major drawback of the waveguide based coupling is the lower reflectance dip and narrow wavelength range which satisfy the coupling condition [114].…”

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