Design Concept of Tissue-Engineered Products for Use in Emergency and Critical Care Medicine

Yoshimitsu, Kengo

doi:10.26717/bjstr.2018.02.000692

Cited by 1 publication

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wound dressings are applied to external wounds, while tissue anti-adhesive products are applied to internal wounds. However, both medical devices should be designed to have a common function that facilitates the wound healing process [1] [2] [3] [4]. The wound dressings need to facilitate the healing process under the impaired conditions such as burn injury and intractable skin ulcer.…”

Section: Introductionmentioning

confidence: 99%

Design of Medical Devices Using Spongy Sheet Composed of Hyaluronic Acid and Collagen

Yoshimitsu¹,

Ohno²,

Suzuki³

et al. 2020

OJRM

Self Cite

View full text Add to dashboard Cite

This research aims to obtain useful information for development of medical devices such as wound dressing and tissue anti-adhesive product, using a spongy sheet composed of hyaluronic acid (HA) and collagen (Col). The spongy sheets were manufactured by freeze vacuum drying of HA and Col aqueous solution, followed by UV irradiation to introduce intermolecular crosslinks between Col molecules. These spongy sheets are referred to as Sponge-A (ratio of HA/Col = 5/1) and Sponge-B (ratio of HA/Col = 5/5). Both surfaces of Sponge-A and Sponge-B treated with UV irradiation for 15 minutes are referred to as Sponge-A-15 and Sponge-B-15, respectively. The weight change of spongy sheet was determined by immersing a peace of spongy sheet in water at 37˚C. The weight of sponge-A-15 collected 1/2, 1, 3, 7 days after immersion in water was 63.5%, 62.1%, 56.6%, 54.4% of the original weight, respectively. The weight of Sponge-B-15 was 78.3%, 76.7%, 79.1%, 71.9% of the original weight, respectively. The weight change of spongy sheet was determined by immersing a peace of spongy sheet in water containing collagenase at 37˚C. The weight of Sponge-A-15 collected 6, 8, 10, 12 hours after immersion in water containing collagenase (0.0005 w/v%) was 65.7%, 59.8%, 57.9%, 55.2% of the original weight, respectively. The weight of Sponge-B-15 was 63.5%, 52.1%, 42.0%, 43.2% of the original weight, respectively. This spongy sheet is considered to have the unique structure, where HA molecules are entrapped in an intermolecular cross-linked network structure of Col molecules. When immersed in water containing collagenase, the weight loss of spongy sheet is accelerated by easy extraction of HA molecules from the enzymatic degraded Col network structure.

show abstract

Section: Introductionmentioning

confidence: 99%