Design and theoretical evaluation of a novel microfluidic device to be used for PCR

Bu, Minqiang; Melvin, T.; Ensell, G.; Wilkinson, James S.; Evans, A G R

doi:10.1088/0960-1317/13/4/321

Cited by 124 publications

(107 citation statements)

References 18 publications

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“…The fluid film thickness, given by h + δ i in the presence of diaphragm deflection, does not vary with in-plane coordinates x and y. As shown in the appendix, this greatly simplifies the solution of equation (4). In particular, if the fluid chamber is symmetric about the y-axes, we obtain the hydrodynamic force…”

Section: Fluid Flowmentioning

confidence: 97%

“…Analytical and numerical calculations of static diaphragm deflections and pumping stroke volumes have been considered for piezoelectric peristaltic micropumps [25]. Also restricted to static characteristics, piezoelectric [4] and electrostatic [26] peristaltic pumps have been modeled by assuming the flow rate to be proportional to the actuation frequency and stroke volume, which is determined from the diaphragm motion by ignoring its interaction with fluid flow. More recently, a lumped-parameter analysis has been reported for diaphragmbased micropumps working peristaltically using active valves driven by general actuation schemes [27].…”

Section: Introductionmentioning

confidence: 99%

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Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

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This paper presents lumped-parameter simulation of dynamic characteristics of peristaltic micropumps. The pump consists of three pumping cells connected in series, each of which is equipped with a compliant diaphragm that is electrostatically actuated in a peristaltic sequence to mobilize the fluid. Diaphragm motion in each pumping cell is first represented by an effective spring subjected to hydrodynamic and electrostatic forces. These cell representations are then used to construct a system-level model for the entire pump, which accounts for both cell-and pump-level interactions of fluid flow and diaphragm vibration. As the model is based on first principles, it can be evaluated directly from the device's geometry, material properties and operating parameters without using any experimentally identified parameters. Applied to an existing pump, the model correctly predicts trends observed in experiments. The model is then used to perform a systematic analysis of the impact of geometry, materials and pump loading on device performance, demonstrating its utility as an efficient tool for peristaltic micropump design.

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Section: Fluid Flowmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Lin¹,

Yang²,

Xie³

et al. 2006

J. Micromech. Microeng.

View full text Add to dashboard Cite

show abstract

“…(3) (with eqns. (4) and (6) substituting for F e and F h ), (7) and (8). With the chamber model above, the pump can be represented as a system consisting of the three chambers and the inlet and outlet channels leading to and from the pump, as illustrated in Fig.…”

Section: Modeling and Analysismentioning

confidence: 99%

“…In addition, we present a lumpedparameter model to analyze the operation of the peristaltic pump. With the model, the dynamics of peristaltic pumping, not addressed by existing micro pump models, [8][9][10] are appropriately investigated. We consider the dynamics of individual pumping chambers and account for the interactions of such component dynamics by a system representation of the peristaltic pump.…”

Section: Introductionmentioning

confidence: 99%

Surface micromachined electrostatically actuated micro peristaltic pump

et al. 2004

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An electrostatically actuated micro peristaltic pump is reported. The micro pump is entirely surface micromachined using a multilayer parylene technology. Taking advantage of the multilayer technology, the micro pump design enables the pumped fluid to be isolated from the electric field. Electrostatic actuation of the parylene membrane using both DC and AC voltages was demonstrated and applied to fluid pumping based on a 3-phase peristaltic sequence. A maximum flow rate of 1.7 nL min 21 and an estimated pumping pressure of 1.6 kPa were achieved at 20 Hz phase frequency. A dynamic analysis was also performed with a lumpedparameter model for the peristaltic pump. The analysis results allow a quantitative understanding of the peristaltic pumping operation, and correctly predict the trends exhibited by the experimental data. The small footprint of the micro pump is well suited for large-scale integration of microfluidics. Moreover, because the same platform technology has also been used to fabricate other devices (e.g. valves, electrospray ionization nozzles, filters and flow sensors), the integration of these different devices can potentially lead to versatile and functional micro total analysis systems (mTAS).

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“…Piezoelectric materials [1][2][3] which can achieve the conversion between mechanical and electrical energy are widely used in piezoelectric functional devices including sensors, actuators and energy harvesters. Because of the excellent characteristics of the piezoelectric device, it is often used in the field of high technology.…”

Section: Introductionmentioning

confidence: 99%

Study on the interactions between the coatings of electric conductor or dielectric media and piezoelectric substrate in the piezoelectric functional devices

2017

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Because that most of piezoelectric functional devices are combined with the coatings of electric conductor or dielectric media and the piezoelectric substrate, the study on the interactions between them is valuable for their advanced design. In this paper, a method for the electro-mechanical coupling fields in these piezoelectric functional devices is presented. Firstly, the two-dimensional Green’s function for a normal line force or line charge is derived. Then, based on the obtained Green’s function, the interaction mechanism between the coatings of electric conductor or dielectric media and the piezoelectric substrate is studied. Finally, the electro-mechanical coupling fields under arbitrary loads are obtained by superposition principle and Gauss integration. Numerical results show that this method has high computational precision, efficiency and stability. And it can be used to improve the reliability and working performance of the piezoelectric functional device effectively.

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Design and theoretical evaluation of a novel microfluidic device to be used for PCR

Cited by 124 publications

References 18 publications

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

Surface micromachined electrostatically actuated micro peristaltic pump

Study on the interactions between the coatings of electric conductor or dielectric media and piezoelectric substrate in the piezoelectric functional devices

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