Design and testing of a polymeric microgripper for cell manipulation

Solano, Belen; Wood, David

doi:10.1016/j.mee.2007.01.153

Cited by 82 publications

(50 citation statements)

References 9 publications

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“…However, not only do such micro-manipulators have to work within the liquid environment that supports the biological cells, they have to operate at low temperatures (<50 °C) and with controllable handling forces (<40 µN), so as to not to cause any damage. As noted in earlier work [2], our design places the actuation electrodes on one arm only. In operation, this arrangement creates a maximum temperature difference between the two arms.…”

Section: Introductionmentioning

confidence: 98%

“…where the same material, usually polysilicon, is used to produce the heating and the desired expansion. Our microgripper is made from two layers of SU-8 polymer, with embedded chromium/gold tracks to provide the electrothermal heating, and has been described previously ( Figure 1, detailed in [2]). The device operation is controlled by applying a current through the conducting layer, where the dissipated power heats the surrounding material and the structure deflects in-plane due to the differential thermal expansion of its constituent parts.…”

Section: Introductionmentioning

confidence: 99%

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Modelling and experimental verification of heat dissipation mechanisms in an SU-8 electrothermal microgripper

Solano

Merrell

Gallant

et al. 2014

Microelectronic Engineering

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NOTICE: this is the author's version of a work that was accepted for publication in Microelectronic Engineering. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. A denitive version was subsequently published in Microelectronic Engineering, 124, 25 July 2014, 10.1016/j.mee.2014.06.002. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Modelling and Experimental Verification of Heat Dissipation Mechanisms in an SU-8 Electrothermal MicrogripperBelen Solano AbstractWithin this work, a microgripper based on a hot-cold arm principle was tested to give a greater understanding of the associated heat dissipation methods. Experiments were conducted in air at atmospheric and sub-atmospheric pressure, and in helium, argon and helium at sub-atmospheric pressure. The change in deflection, when using gases with different thermal conductivities and at varying pressures showed the significance of conduction through the atmosphere. The experimental results were found to verify a theoretical model created previously by this group, and a further model developed independently; both predicted the deflection that a given current would cause.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Modelling and experimental verification of heat dissipation mechanisms in an SU-8 electrothermal microgripper

Solano

Merrell

Gallant

et al. 2014

Microelectronic Engineering

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“…The micromanipulation technology with device dimensions and material properties compatible to biological cell finds important applications in the biomedical manipulation [7,8]. In considering the different requirements of manipulating micro particles in liquid environment, several mechanical microgrippers have been developed for these applications [1,3,[6][7][8][9][10][11][12][13][14][15][16][17][18]. Regarding the manipulation of micro particles in liquid environment, the research on gripping stationary artificial particle [1,3,6,7,[10][11][12]15] and living cell [3,6,9,13,14,16] has been reported.…”

Section: Introductionmentioning

confidence: 99%

Polymer Microgripper with Autofocusing and Visual Tracking Operations to Grip Particle Moving in Liquid

Chang

Chien

2018

Actuators

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Abstract:A visual-servo automatic micromanipulating system was developed and tested for gripping the moving microparticle suspended in liquid well. An innovative design of microgripper integrated with flexible arms was utilized to constrain particles in a moving work space. A novel focus function by non-normalized wavelet entropy was proposed and utilized to estimate the depth for the alignment of microgripper tips and moving particle in the same focus plane. An enhanced tracking algorithm, which is based on Polar Coordinate System Similarity, incorporated with template matching, edge detection method, and circular Hough Transform, was implemented. Experimental tests of the manipulation processes from moving gripper to tracking, gripping, transporting, and releasing 30-50 µm Polystyrene particle in 25 • C water were carried out.

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“…A few of the most frequently used principles are, for example, electro thermal (Volland et al 2007;Stavrov 2010, Colinjivadi et al 2008Solano and Wood 2007;Zeman et al 2006;Voicu et al 2007) electrostatic (Beyeler et al 2007;Wierzbicki et al 2006), piezoelectric (Nah and Zhong 2007;Perez et al 2006), electromagnetic (Kim et al 2005) or are based on the shape memory effect (Zhong and Chan 2007). All these techniques have their specific advantages and disadvantages, e.g.…”

Section: Introductionmentioning

confidence: 99%

Characterization of an electro-thermal micro gripper and tip sharpening using FIB technique

et al. 2010

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A micromachined electro-thermal gripper, first introduced by Ivanova et al. (Microelectron Eng 83:1393-1395, represents a promising candidate for the manipulation and handling of micro or even nano-scaled objects. To further optimize the performance of the device, a detailed electrical and mechanical characterization is needed. Due to the so-called duo-action gripper approach (i.e., a separate actuator for closing and opening action) these investigations focused on the maximum (minimum) opening width being 11.5 lm (3.3 lm), while in rest position a value of 4 lm is feasible. The maximum, electrical input power is limited to 80 mW/actuator element, resulting in a current density of up to 1.27 MA cm -2 in the corresponding metal layers. When applying, however, larger current densities the probability of device failure increases substantially as in combination with an enhanced temperature of about 200°C electromigration effects occur in the metallization. Furthermore, the cut-off frequency and parasitic effects during actuation such as the z-deflection and the increase in length of each arm both showing values of up to 3 lm have been investigated as a function of operation parameters. Finally, the tips of the gripper were sharpened using Focused Ion Beam technique to a radius of less than 1 lm for gripping operations in space-restricted environments or for the manipulation or handling of sub-lm scaled objects.

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Design and testing of a polymeric microgripper for cell manipulation

Cited by 82 publications

References 9 publications

Modelling and experimental verification of heat dissipation mechanisms in an SU-8 electrothermal microgripper

Modelling and experimental verification of heat dissipation mechanisms in an SU-8 electrothermal microgripper

Polymer Microgripper with Autofocusing and Visual Tracking Operations to Grip Particle Moving in Liquid

Characterization of an electro-thermal micro gripper and tip sharpening using FIB technique

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