Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents

Crystal structure of 2-(4-(4-bromophenyl)thiazol-2-yl)isoindoline-1,3-dione, C17H9BrN2O2S

“…The combination between thiazoles and phthalimides was founded in many biologically active compounds, which may act anticonvulsant, anticancer, antimicrobial, antiin ammatory and antifungal [1][2][3][4][5][6]. In proceeds of our work, we report the crystal structure of the title compound (C17H 9 BrN 2 O 2 S).…”

Crystal structure of N-(5-bromo-4-(p-tolyl)thiazol-2-yl)-4-chlorobutanamide, C14H14BrClN2OS

“…2-Aminothiazole derivatives are generally utilized as structural motifs in medicinal chemistry. Several reviews and papers show the application of 2-aminothiazoles in the treatment of a diverse range of di erent diseases like Alzheimer's disease, chronic pain, cancer and Huntington's disease [1][2][3][4][5].…”

Alternate Method for the Dimerization of 2-Benzylidene inden-1-one Derivatives: Synthesis of 1,3-Diaryl-1,3,3a,8a-tetrahydro-8H-spiro[cyclopenta[a]indene-2,2'-indene]-1',8(3'H)-diones

“…They draw attention due to have bioactive properties such as monoamine oxidase inhibitors [3], AChE inhibitors [4], antiproliferative [5], anticancer [6] antioxidant activity [7] and Alzheimer's treatment [8]. In addition, they are valuable compounds from the synthetic point of view because used as starting material in the synthesis of important compounds such as indeno pyrazole [9], indeno pyrimidine [10] and indeno pyridine derivatives [11,12]. 2-Benzylideneinden-1-one derivatives, unlike chalcones, contain a methylene unit in structures so they are given dimerization reaction in basic medium and convert into spiro-dimeric products [13].…”