Design and Synthesis of Pyrazolyl Thiosemicarbazones as New Anticonvulsants

Abstract

A series of pyrazolyl thiosemicarbazone derivatives were synthesized and evaluated for their anticonvulsant activity using the maximal electroshock (MES) method. Interestingly, all compounds prepared showed long duration of protection effect in the MES screens. Among them, compound 5b was considered as the most promising one with an ED50 value of 47.3 mg/kg, and a PI value of 4.8, which was superior to phenobarbital and valproate in the aspect of safety. Furthermore, compound 5b showed protection against seizures induced by pentylenetetrazole suggesting that compound 5b may exert anticonvulsant activity through GABAmediated mechanisms.

Selective determination of Cr(III) ions with novel potentiometric electrodes

“…[ 1,2 ] Thiosemicarbazone derivative molecules are one of the groups of organic molecules that are highly studied by researchers because of their promising biological properties. [ 3–5 ] Besides, thiosemicarbazone derivative molecules have been used as sensor materials, and sensors developed using thiosemicarbazone derivative molecules have been developed for the determination of various ions. [ 6,7 ]…”

“…[1,2] Thiosemicarbazone derivative molecules are one of the groups of organic molecules that are highly studied by researchers because of their promising biological properties. [3][4][5] Besides, thiosemicarbazone derivative molecules have been used as sensor materials, and sensors developed using thiosemicarbazone derivative molecules have been developed for the determination of various ions. [6,7] Potentiometry, which is one of the important research topics in electroanalytical chemistry, is based on the measurement of the potential of an electrode system consisting of one reference and one working electrode.…”

Synthesis and Caracterizations of New Thiosemicarbazone and Thiazole Derivatives From Polycyclic Chiral 1,5‐Diketones

“…[4] When look at the literature, it is seen that there are many studies on thiosemicarbazones and the scope of these studies is generally on the synthesis, biochemistry, structural properties, biological activities and analytical applications of thiosemicarbazones. [5][6][7][8] In the literature, it is seen that various thiosemicarbazone derivatives with antimicrobial, [9] antituberculosis, [10] anti-HIV, [11] anticonvulsant, [12] analgesic, [13] antitumor, [14] and antifungal [15] activities have been reported. In addition, there are many studies on ionophore properties of thiosemicarbazones.…”