Design and synthesis of novel heterocyclic acetamide derivatives for potential analgesic, anti-inflammatory, and antimicrobial activities

Design, synthesis, molecular docking and biological evaluation of imides, pyridazines, and imidazoles derived from itaconic anhydride for potential antioxidant and antimicrobial activities

“…Based on the above observations and the need for ongoing efforts to synthesize a large range of biologically active heterocycles [9], the objectives of the present study were to synthesize various heterocyclic derivatives, such as imides, pyridazines, thiazoles, and benzimidazoles, from a single precursor (itaconic anhydride (ITA)) and to evaluate the in vitro and in silico antioxidant and antimicrobial properties of the new heterocyclic derivatives.…”

2-(2-Methylphenyl)-N-(1,3-thiazol-2-yl)acetamide

“…For the structural similarity of N-substituted 2-arylacetamides to the lateral chain of benzylpenicillin, see: Mijin et al (2008). For our studies of acetamides, see: Nayak et al (2014). Agilent Agilent (Eos, Gemini) diffractometer Absorption correction: multi-scan (CrysAlis RED; Agilent, 2012) T min = 0.582, T max = 1.000 7059 measured reflections 2250 independent reflections 2065 reflections with I > 2(I)…”

“…(Mijin et al, 2008). As part of our ongoing studies of such systems (Nayak et al, 2014) we report herein the crystal structure of the title compound, (I), C 12 H 12 N 2 OS.…”

Computational Modeling, Docking, Synthesis, Characterization, and in vitro Cyclooxygenase Inhibitory Activity of Some Novel Non-Steroidal Anti-inflammatory Prodrugs

“…The interest in synthesizing poly-functional molecules is increasing nowadays. Acetamides can be considered as a poly-functional molecules since their derivatives were found to possess various bioactive properties such as; anthelmintic (Sawant and Kawade, 2011), anticonvulsant (Kamiński et al, 2011) (Jawed et al, 2010), antioxidant (Ayhan-Kılcıgil et al, 2012) (Autore et al, 2010), anti-inflammatory (Jain et al, 2013) (Autore et al, 2010), anti-arthritic (Jain et al, 2013), anti-bacterial (Kanagarajan and Gopalakrishnan, 2012) (Nayak et al, 2014), antifungal (Bardiot et al, 2015) (Kidwai et al, 2012) (Kanagarajan, Thanusu and Gopalakrishnan, 2010), and anti-viral properties (Babkov et al, 2015) (Kai et al, 2001).…”