“…Interestingly, these derivatives are also found in the structure of commercially available drugs such as Quinacillin (an antibacterial drug), [3] Varenicline (a partial agonist drug used for smoking cessation), [4] Brimonidine (used to treat open‐angle glaucoma, ocular hypertension, and rosacea), [5] Panadiplon (an anxiolytic drug), [6] Morinamide (an anti‐tuberculosis agent), [7] and Glipizide (an anti‐diabetic agent) [8] (Figure 1). Another fascinating aspect of quinoxaline and pyrazine scaffolds is that when combined with other bioactive fragments, especially with indole or indene, they create compounds with a variety of pharmaceutical properties [9–11] . These fused heterocycles also possess applications in diverse technical fields, like in the production of organic semiconductors, [12] metal complexes, [13] cavitands, [14] dyes, [15] luminescent materials, [16] and more.…”