Design and synthesis of novel indole derivatives with aggregation-induced emission and antimicrobial activity

Sayed, Mostafa; Younis, Osama; Hassanien, Reda; Ahmed, Mostafa; Mohammed, Ahmed A. K.; Kamal, Ahmed A. M.; Tsutsumi, Osamu

doi:10.1016/j.jphotochem.2019.111969

Cited by 35 publications

(29 citation statements)

References 39 publications

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“…AIE molecules have also been used to detect biomacromolecules in organisms and live cells a sensitive and selective manner [24,25]. For this kind of applications, the organic molecules must have AIE and bioactive and biocompatible properties [26]. However, the syntheses of organic molecules have AIE behavior in addition to their biocompatibility are rarely reported.…”

Section: Introductionmentioning

confidence: 99%

“…However, the syntheses of organic molecules have AIE behavior in addition to their biocompatibility are rarely reported. Therefore, to increase the number of AIE‐ and biologically active organic compounds, it has been recently realized that fuse heterocyclic compounds can exhibit AIE behavior by implementing multiplying twisted and rotatable aryl groups [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization, and photophysical properties of some new thieno[2,3‐b]pyridines bearing phenylethenyl moiety

EL‐Mahdy

Bakhite

Abdel‐Hafez

et al. 2021

Journal of Heterocyclic Chem

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5‐Acetyl‐3‐cyano‐6‐methyl‐4‐(2‐phenylethenyl)pyridine‐2(1H)‐thione (2) was synthesized by interaction of cinnamylidene‐2‐cyanothioacetamide 1 and acetylacetone or via one‐pot reaction of E‐cinnamaldehyde, 2‐cyanothioacetamide, and acetylacetone. Reaction of 2 with ethyl iodide (3a) or N‐chloroacetyl derivative of aromatic amines 3b–e in boiling ethanol containing sodium ethoxide gave the corresponding thioether 4a and 5‐acetyl‐3‐amino‐2‐(N‐arylcarbamoyl)‐6‐methyl‐4‐(2‐phenylethenyl)thieno[2,3‐b]pyridines 5b–e, respectively. Compound 5e was reacted with 2,5‐dimethoxytetrahydrofuran or triethyl orthoformate to furnish pyrrolylthienopyyridine 6 or pyrdiothienopyrimidinone 7, respectively. The photophysical properties of 5b, 5c, 5e, and 7 were fully studied and the obtained results included herein. The fluorescence data confirmed that compounds 5b, 5c, 5e, and 7 exhibit aggregation‐induced emission behavior with high absolute quantum yields.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and photophysical properties of some new thieno[2,3‐b]pyridines bearing phenylethenyl moiety

EL‐Mahdy

Bakhite

Abdel‐Hafez

et al. 2021

Journal of Heterocyclic Chem

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“…1). M. Sayed et al synthesized indolylthienopyrimidine derivatives that are thermally stable and have the ability to exert anti-microbial activities [38]. Indigo is probably the oldest and the most famous colorant based on indole.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Medicinally Important Indole Derivatives: A Review

Sharma¹,

Qadir²,

Amin³

et al. 2021

TOMCJ

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Indoles constitute a widely occurring functional group in nature and are present in an extensive number of bioactive natural products and medicinally important compounds. As a result, exponential increases in the development of novel methods for the formation of indole core along with site-specific indoles have been established. Conventional methods for the synthesis of indoles are getting replaced with green methods involving ionic liquids, water as a solvent, solid acid catalyst, microwave irradiation and the use of nanoparticles under solvent-free conditions. In addition, there are immense applications of the substituted indoles in diverse fields.

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“…Indole derivatives have attracted attention over a few decades, because of many activities such as antimicrobials [3], pharmacological, anti-fungals [4], and anti-tumor [5], anti-inflammatories, antivirals [6], antibiotics drugs [7], and anticancer [8] (Fig. 2).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Indoles Derivatives Using Metal Free Catalyst in Organic Reactions

Das¹,

Dangi²,

Kashaw³

2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: Indole derivatives are one of the most flexible and common nitrogen-based skeletons and often used in the synthesis of numerous heterocyclic compounds, having biological or medicinal importance. Many indole derivatives have been isolated naturally from plants, fungi, and marine organisms and are highly important due to their pharmaceutical activities. They also play a significant character in polymer and dye industries as well as in the agriculture sector. There exists an immense potential for designing and methodology development for the synthesis of indole based heterocyclic scaffold structure with desire chemical and biomedical relevance.Result and Discussion: In this present review, we outlined the recent applications of indoles in the onepot multi-component reaction using metal free catalysts for the preparation of various heterocyclic scaffolds and their corresponding biological activities are also discussed.

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Design and synthesis of novel indole derivatives with aggregation-induced emission and antimicrobial activity

Cited by 35 publications

References 39 publications

Synthesis, characterization, and photophysical properties of some new thieno[2,3‐b]pyridines bearing phenylethenyl moiety

Synthesis, characterization, and photophysical properties of some new thieno[2,3‐b]pyridines bearing phenylethenyl moiety

Synthesis of Medicinally Important Indole Derivatives: A Review

Synthesis of Indoles Derivatives Using Metal Free Catalyst in Organic Reactions

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