Design and Synthesis of Novel Cage like CuFe2O4 Hollow Nanostructure as an Efficient Catalyst for Synthesis of 4,4′-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s

Pyrazolone-type compounds: synthesis andin silicoassessment of antiviral potential against key viral proteins of SARS-CoV-2

“…Generally, the literature on these particular types of compounds is relatively scarce, and the research is mainly focused on the development of novel eco-friendly synthetic methods employing various catalysts, mostly ionic liquids and nanoparticles. [45][46][47][48][49][50][51][52] Following such a trend, the synthesis of pyrazolone analogues a-t was accomplished in the reactions of 5-methyl-2,4-dihydro-3H-pyrazol-3-one with different aromatic aldehydes in the presence of diethanolamine as a catalyst, and in ethanol and under reux. To optimise reaction conditions, the model reaction between benzaldehyde and 5-methyl-2,4-dihydro-3Hpyrazol-3-one was investigated in the presence of various catalysts and solvents (Table 1).…”

“…To our knowledge, crystal data on these particular compounds are insufficient. Moreover, all articles related to these compounds presented the OH-tautomeric forms of both pyrazolone rings, [45][46][47][48][49][50][51][52] including the crystal structure of compound a. 57 Single crystal X-ray analysis shows that the compound consists of a substituted phenyl ring and two 3-methyl-5-pyrazolone rings connected through the benzyl C1 atom.…”

Pd(0)‐guanidine@MCM‐41: a very effective catalyst for rapid production of bis (pyrazolyl)methanes

“…In order to demonstrate the superiority of our catalyst to other reported catalysts for the synthesis of bis (pyrazolyl)methanes, the results of the reaction of 4-chlorobenzaldehyde with phenylhydrazine and ethyl acetoacetate for the pseudo five-component reaction [69] AP-SiO 2 CH 3 CN, rt ii 5 97 3.2 0.64 [70] DCDBTSD Solvent-free, 80 C i 40 80 8.0 0.20 [71] CuFe 2 O 4 Solvent-free, 80 C i 8 96 24.0 3.00 [72] [Pyridine-SO3H]Cl Solvent-free, 50 C ii 8 94 94 11.75 [73] SASPSPE EtOH, Reflux ii 132 85 25 0.18 [74] Ni-guanidine@MCM-41 NPs Acetonitrile, 80 C ii 20 90 11.2 0.56 [34] (i) as well as the outcomes of the reaction of 4-chlorobenzaldehyde with 3-methyl-1-phenyl-1Hpyrazol-5(4H)-one for the pseudo three-component reaction (ii) are presented in Table 5. As it can be seen in Table 5, Pd(0)-guanidine@MCM-41 was better than the other catalysts in terms of two or more of these factors: TON, TOF, the reaction temperature, time and yield.…”

Highly Active and Reusable Cu/C Catalyst for Synthesis of 5-Substituted 1H-Tetrazoles Starting from Aromatic Aldehydes

“…Previously, we have reported on copper nanoparticles on charcoal (Cu/C) as an excellent heterogeneous cat-alyst for the synthesis of triazole, 38 propargylamine, 39 benzimidazole, 40 2-amino-3-cyanopyridine, 41 indazole 42 and imidazole derivatives. 43 In continuation of our studies on the synthesis of heterocycles and the use of heterogeneous catalysts in organic reactions, [44][45][46][47][48][49][50][51][52][53][54][55][56] we describe here a new strategy for the preparation of tetrazole derivatives. The strategy is based on a one-pot three-component [3+2]cycloaddition reaction between aldehydes, hydroxylamine hydrochloride and sodium azide using Cu/C as heterogeneous catalyst.…”