Design and synthesis of novel C14-urea-tetrandrine derivatives with potent anti-cancer activity

A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

“…Tetrandrine has broad-spectrum antitumor effects (Bhagya and Chandrashekar 2018;Liu 2017;Liu et al 2016) in many types of cancer cells, including human liver cancer (Zhang et al 2018a;Yu and Ho 2013), osteosarcoma Lu et al 2017), oral cancer (Lien et al 2017;Huang et al 2013), colon carcinoma (Meng et al 2004;Li et al 2019), gastric cancer (Bai et al 2018;Qin et al 2013), brain glioblastoma multiforme GBM 8401 cancer (Jiang et al 2019) and lung carcinoma (Chow et al 2018;Cho et al 2009). It also exhibits antineoplastic activity against gallbladder carcinoma (Zhu et al 2014), thyroid carcinoma B-CPAP cells ), prostatic carcinoma PC3 cells (Lan et al 2018), esophageal cancer , breast cancer (Guo and Pei 2019), pancreatic cancer (Singh et al 2018), nasopharyngeal carcinoma (Lin et al 2016(Lin et al , 2017b, acute megakaryoblastic leukemia (Liu et al 2017c), cervical cancer (Zhang et al 2018b) and renal carcinoma (Chen et al 2014(Chen et al , 2017a cells. Although tetrandrine exhibited broad anti-tumor effects, a number of these studies lacked positive controls or anti-tumor evaluation of tetrandrine in vivo.…”

“…,Zhang et al (2018d),Yu and Ho (2013),Tian et al (2017),Lu et al (2017),Lien et al (2017),Huang et al (2013),Meng et al (2004),Zhu et al (2014),Zhang et al (2017a, b),Lan et al (2018),Bai et al (2018),Qin et al (2013),Wang et al (2012),Guo and pei (2019), Singh et al (2018), Liu et al (2017a, b, c), Lin et al (2016), Zhang et al (2018a, b, c, d), Jiang et al (2018), Chow et al (2018), Cho et al (2009), Chen et al (2014, 2017a, b), Wang et al (2014a, b, 2017a, b, c), Li et al (2015a, b, c, d), Fan et al (2017), Luo et al (2016), Chen et al (2017a, b), Lee et al (2017), Wang et al (2011), Li et al (2017a, b), Guo et al (2016), Shi et al (2017), Wang et al (2013), Hua et al (2015), Gao et al (2017), Payon et al (2019), Rattanawong et al (2018), Zhu et al (2017), Wu et al (2001), Tzeng et al (1990), Uche et al (2016), Konkimalla and Efferth (2010), Huang et al (1998), Makarasen et al (2011), Ma et al Lv et al (2016), Ruan et al (2013), Chiou et al (2006), Bao et al (2016), Li et al (2015a, b, c, d), Han et al (2015), Zhang et al (2001), He et al (2011), Koh et al (2003), Lin et al (2009), Kim et al (2001), Hošt'álková et al (2015), Kongkiatpaiboon et al (2016), Dong et al (2015), Ingkaninan et al (2006), Hao et al Huang et al (2016), Zhang et al (2014), Zhao et al (2004) Antinociceptive effects 9, 10, 39 Zhao et al (2014), Zhang and Fang (2001), Fang et al (2005), Montrucchio et al (2013) Other central effects 9, 44, 49, 58 Chen et al (2015), Ma et al (2016), Chen et al (2013), Ma et al (2016), Indra et al (2002), Kukula-Koch et al (2017), Manuszak et al (2018), Meade et al (2015), Hicks et al Yu et al (2004), Huang et al (2016), Zhang et al (2014), Wang et al (2016a, b, c), Huang et al (2011), Teng et al (1991…”

Improved Antioxidant and Antifungal Activity of Chitosan Derivatives Bearing Urea Groups

“…had synthesized a series of novel C 14 ‐urea‐tetrandrine derivatives. They reported that the C 14 ‐urea substituted derivatives held up fairly well in anticancer activity and they could be used as a potential anticancer drug candidate . Several 1‐phenyl‐3‐(5‐(pyrimidin‐4‐ylthio)‐1,3,4‐thiadiazol‐2‐yl)urea derivatives with remarkable effects on human chronic myeloid leukemia cell line K562 were also designed.…”

Design, Synthesis of Novel Tetrandrine-14-l-Amino Acid and Tetrandrine-14-l-Amino Acid-Urea Derivatives as Potential Anti-Cancer Agents

“…As a potential anticancer agent with multiple mechanisms of action, the structural modificatio tetrandrine is an attractive subject for many research groups. Since the 21st century, structur odifications have mainly focused on introducing halogens and alkyl groups at the C5 and C sitions of tetrandrine [24][25][26], or quaternary ammonium salts at the N2 and N1 positions [27,28 cently, our group prepared a serious of C14-amino substituted tetrandrine derivatives whic hibited satisfactory inhibitory effects on human hepatocellular carcinoma (HCC), huma kemia (HEL and K562), human breast carcinoma (MDA-MD-231), human PCa (PC3), and huma elanoma (WM9) cell lines [29][30][31]. Even though these derivatives are reported as potenti ticancer agents, their poor water solubility and low bioavailability limits their application fo veloping lead anticancer compounds [32,33].…”