Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents

Biophysical study on the interaction between two palladium(II) complexes and human serum albumin by Multispectroscopic methods

“…Duan group described triazole-dithiocarbamate hybrids as potential anticancer agents. Also, Pd(II) complex with n-propyldithiocarbamate ligand and metal complexes derived from thalidomide based dithiocarbamate have been reported as anticancer agents [13][14][15]. Nitrogen donor heterocyclic ligands such as 2,2′-bipyridine (¼bipy), 1,10-phenanthroline ( ¼phen) or pyridine ( ¼py) have shown promising antitumor characteristics [16].…”

“…Dithiocarbamates have attracted considerable interest because of their diverse activities. Dithiocarbamate derivatives have been studied as antifungal, anti-bacterial, anti-cancer and carbonic anhydrase inhibiting [11][12][13]. Duan group described triazole-dithiocarbamate hybrids as potential anticancer agents.…”

Design, synthesis and biological evaluation of N -((1-benzyl-1 H -1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1 H -pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors

“…They have taken a leading position in the medicinal chemistry and are also being used as important pharmacophores in the field of drug design. In additon, triazole is a unique template that is associated with a number of biological activities and this moiety is an attractive option to use it as a structural component in the design of new molecules as it is stable in acidic/basic conditions [19], also has a high dipole moment and affords the possibility of forming hydrogen bonds with bimolecular targets [20]. …”

Synthesis and antitumor activity of tetrahydrocarbazole hybridized with dithioate derivatives

“…Molecular hybridization approach represents an effective tool to design novel and highly active drugs since these hybridized molecules can act on multiple targets and thus can overcome drug resistance 28,29 . Many literature reported the molecular hybridization and anticancer activity of dithiocarbamates with thalidomide 8 , butenolide 12 , 1,2,3-triazoles 14,15 , quinazolines 9,11,16,17 , chromones 13 , sulphonamides 10 and saccharin derivatives 2 . However, to the best of our knowledge, their molecular hybridization with tetrahydrocarbazoles to afford anticancer agents have not been reported before.…”