Abstract:Steroid derivatives modified with nitrogen containing heterocycles attract attention as anticancer agents for prostate cancer treatment. In this study we have developed a simple and convenient procedure for preparation of 17(20)-21-norpregnene and androst-16-ene 2'-oxazolinyl and 2'-benzoxazolyl derivatives, based on the reaction of an appropriately modified steroidal carboxylic acid with 1,2-amino alcohols or o-aminophenol. Using this method we conducted synthesis a series of new steroid hybrids differing eit… Show more
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