Design and Synthesis of New Homo- And Heterometal Coordination Compounds of Germanium(iv) for Preparation of Low Toxic Drugs With a Wide Therapeutic Action

Abstract

Coordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands -biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism (nicotinic, citric, tartaric, 1-hydroxyethylidendiphosphonic acids, nicotinamide) are synthesized for the first time on the Department of General Chemistry and Polymers of Odessa Mechnikov National University. The favorable activity of the synthesized compounds on cardiovascular and chronic respiratory diseases, senile pneu-on cardiovascular and chronic respiratory diseases, senile pneumonia, neuropsychiatric and metabolic disorders, ischemic heart diseases, etc. is described. Thus, the influence of 1-hydroxyethylidendiphosphonatogermanate (medgerm) on CNS, its anxiolytic activity and absence of both hypnotic and myorelaxant effects has been shown. Cardioprotector properties of magnesium hydroxyethylidendiphosphonategermanate as a potential effective and safe drug with the high antihypertensive and antiarrhythmic activity have been found out. The interferoninductive and immunostimulatory activity of germanium(IV) compounds with 1-hydroxyethylidendiphosphonic, nicotinic acids, nicotinamide, pyracetam has been studied. Injection of these drugs (concentration 100-125 μg/ml) causes the 100 % delay of cytopathic action of vesicular stomatitis virus in the cell cultures that demonstrates the ability of compounds to increase essentially cells stability. The perspectives of germanium coordination compounds as interferon inductors and as immune pharmaceuticals for prevention the disbalance of the immune system are reviewed.

Selective Recognition of Different Tartratogermanate Anions using 1,10‐phenantroline Complexes of Fe(II), Co(II), Ni(II)

“…Germanium does not only take part in the process of oxygen transfer and prevents the development of bloody hypoxia in this way, but also promotes induction of gamma-interferon, has a positive influence on cardiovascular and chronic respiratory diseases, senile pneumonia, neuropsychiatric and metabolic disorders, ischemic heart diseases, tumors. [1][2][3][4][5][6][7][8][9] It was established that germanium stimulates production of gamma-interferon. Germanium transports oxygen to the all parts of human body, where it binds to H + ions and lowers their harmful effect on the cell.…”

“…Germanium transports oxygen to the all parts of human body, where it binds to H + ions and lowers their harmful effect on the cell. [2] The novel synthesis strategy that provides combination of biological properties of Ge (IV) (p-), Fe (II), Co(II), Ni (II) (delements) and two types of ligands: chelating polydentate tartaric acid and bidentate heterocyclic 1,10-phenantroline has been developed. It involves selective complexation, recognition and isolation of different anions-a recently new scientific direction that has become in the centre of interest only 30 years ago.…”

The influence of coordinative tartrate and malatogermanate compounds on the activity of ?-L-rhamnosidase preparations from Penicillium tardum, Eupenicillium erubescens and Cryptococcus albidus

“…As modifiers of enzyme activity, we used germanium coordination compounds (H 4 Tart -tartaric acid, phen -1,10-phenanthroline, 2,2′-bipyridine). For their synthesis, the original methods were developed [20][21][22], which involve stepwise interaction of tartrate(malate-)germanate acids and ethanol solutions of complexes of d-metal ions (Cu 2+ , Ni 2+ , Fe 2+ , Zn 2+ ) and aromatic amines (1,10-phenanthroline, 2,2′-bipyridine): (11). All compounds were comprehensively characterized by modern physical and chemical methods: elemental analysis, infrared spectroscopy, thermogravimetric analysis, single crystal XRD.…”

“…α-Lrhamnosidases, there are several approaches, one of which is the use of substances that enhance their catalytic effect. As α-L-rhamnosidase modifiers , coordination compounds of germanium, an essential ultratrace element, with various biologically active ligands have received increasing interest recently [10][11][12]. Due to the peculiarities of electronic configuration, germanium is able to promote tissue oxygenation, enhance blood circulation, strengthen the immune system, promote γ-interferon induction, normalize metabolism, and exhibit antitumor effect [13][14][15][16].…”

Synthesis and Structural Characteristics of Bis(Citrate)Germanates(IV) (Hbipy)2[Ge(HCit)2]·2H2 and [CuCl(bipy)2]2[Ge(HCit)2]·8H2O

“…The pharmacological activity of some of these compounds has been approved [8]. The complexes of germanium(IV) are interesting materials for modern technics [9,10].…”