Design and Synthesis of Naphthalene-Pregnen Derivative Using Some Strategies

Figueroa‐Valverde, Lauro; Díaz-Cedillo, Francisco; Elodia, García-Cervera; Eduardo, Pool-Gómez; María, López-Ramos; Marcela, Rosas-Nexticapa; Lenin, Hau-Heredia; Beatriz, Sarabia-Alcocer; Marquez-Estrella, Gabriela

doi:10.14233/ajchem.2016.19054

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previously reported ischemia reperfusion method was used to induce heart failure 12 ; in this way, after of 15-minute equilibration time, the hearts were subjected to ischemia for 30 minutes by turning off the perfusion system. Then, the perfusion system was restarted, and the hearts were reperfused by 30 minutes with Krebs-Henseleit solution.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

et al. 2022

View full text Add to dashboard Cite

Background There are studies, which suggest that some diazocine derivatives can exert effects on the cardiovascular system; however, these effects are not very clear. Objective The aim of this research was to evaluate the biological activity of a diazocine derivative against heart failure translated as area infarct. Methods Biological activity produced by diazocine derivatives against heart failure was determinate using an ischemia/reperfusion injury model. Besides, to characterize the molecular mechanism of effect exerted by diazocine derivative on left ventricular pressure (LVP) was determinate in an isolated rat heart model using nifedipine, PINAME TXA2, and quinalizarin as controls. Results The results showed that diazocine derivative decrease the infarct area and increase the LVP. However, the effect produced by diazocine derivative on LVP was inhibited in the presence of quinalizarin. Conclusions The results indicate that biological activity produced by diazocine derivative on left ventricular pressure is through protein CK2 activation; this phenomenon could be translated as a decrease in both infarct area and heart failure.

show abstract

Section: Methodsmentioning

confidence: 99%

Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The testosterone derivative and pregnenolone (OTBS-Testosterone and OTBDSpregnenolone) were prepared using methods previously reported 20 . The other reagents used in this study were purchased from Sigma-Aldrich Co. Ltd.…”

Section: General Methodsmentioning

confidence: 99%