Design and synthesis of imidazolo-1, 2,3-triazoles hybrid compounds by microwave-assisted method: Evaluation as an antioxidant and antimicrobial agents and molecular docking studies

Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

“…Thus, in the search for novel medicinal compounds, microwave synthesis is highly effective in creating new 1,2,3triazole-containing compounds with high yields, low reaction times, and environmentally friendly methods. 100 Scheme 9 Synthesis of imidazole containing 1,2,3-triazole derivatives via 4-hydroxy benzaldehyde. 100…”

“…Compounds 112a-h were then reacted with benzil 113 and ammonium acetate under microwave conditions to yield the target compounds 114a-h (Scheme 9). 100 Amine et. al.…”

Agar-entrapped sulfonated DABCO: Agelly acidic catalyst for the acceleration of one-pot synthesis of 1,2,4-triazoloquinazolinone and some pyrimidine derivatives

“…Because of their special structural characteristics, triazoles are considered as important class of heterocyclic compounds showing interesting biological, pharmaceutical and therapeutic activities including antifungal [2] , antimicrobial [3] , [4] , [5] , [6] , [7] , [8] , anti-cancer [9] , anticonvulsant [10] , antihypertensive [11] , and anti-viral [12] . In this regard many drugs containing triazole moiety are manufactured, which of them Ribavirin or Copegus (an antiviral), Alprazolam (an anxiolytic), Letrozole (an anticancer), and Flusilazole (an organosilicon fungicide) [13] are examples ( Fig.…”

Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4H-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics

“…Based on the last 40 years of academic and pharmaceutical industry inventions, only bedaquiline was the first novel anti-TB drug permitted by the United States Food and Drug Administration (US FDA) authority in December 2012, for the treatment of MDR-TB, [6] while delamanid was the second anti-TB agent to be approved by the European Medicines Agency in late 2013 [7] and pretomanid was the third drug to be approved by the US FDA in August 2019 [8,9] (Figure 1). Triazole pharmacophore with various functional groups/substitutions has been reported for its promising anti-TB [10][11][12][13][14][15][16][17][18][19][20][21], antiviral [22], antibacterial [23,24], antifungal [25,26], antioxidant [27][28][29][30], and antiglycation properties [31]. In addition, it also serves as an opener of Ca( 2+ )-activated potassium (maxi-K) channels [32] and demonstrates molluscicidal [33], hypoglycemic [34], antihypertensive and blood platelet aggregation inhibition [35] activities.…”