Design and synthesis of dinuclear bismuth(III) complexes with potent ribonuclease-like activity
Yutaro Hanatani,
Takashi Kurohara,
Yasunobu Yamashita
et al.
Abstract:Several metal complexes with ribonuclease-like activity have been developed as chemical biology tools for RNA regulation. However, their RNA-cleavage activity is insufficient under physiological conditions. Here, we have identified novel dinuclear bismuth(III) complexes that contain dipyridine/dipicolinate-based ligands as artificial ribonucleases to induce efficient RNA cleavage. Our optimization studies of the ligand structure indicated that the dipyridine/dipicolinate scaffold of the ligands plays a key rol… Show more
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