Design and Synthesis of Conjugated Polyelectrolytes

Pu, Kanyi; Wang, Guan; Liu, Bin

doi:10.1002/9783527655700.ch1

Cited by 6 publications

(5 citation statements)

References 125 publications

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“…Because the nearinfrared (NIR) light can realize the deep-tissue penetration with a quite low level of the total extinction coefficient and is minimal absorbed by biological tissues, 7−11 various organic and inorganic phototherapeutic agents with optical absorbance in the NIR region have exhibited inspiring photothermal therapeutic efficacy in preclinical experiments. 6,12−17 As an important kind of macromolecules, conjugated polymers, especially in the doping of polyacetylene, 18,19 were successfully prepared and widely applied in a number of fields, 20 such as solar cells, bioimaging, and biomedicine. 21 Conjugated polymers are polymers with conjugated bond structures and repeating chemical units with delocalized π-electron systems.…”

Section: Introductionmentioning

confidence: 99%

“…As an important kind of macromolecules, conjugated polymers, especially in the doping of polyacetylene, , were successfully prepared and widely applied in a number of fields, such as solar cells, bioimaging, and biomedicine . Conjugated polymers are polymers with conjugated bond structures and repeating chemical units with delocalized π-electron systems.…”

Section: Introductionmentioning

confidence: 99%

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Conjugated-Polymer-Based Nanomaterials for Photothermal Therapy

Wang

Meng

Song

et al. 2020

ACS Appl. Polym. Mater.

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In the past few decades, the development of excellent materials for the treatment of disease via noninvasive photothermal therapy has received increasing attention. Among a number of kinds of nanomaterials, conjugated-polymer-based nanomaterials, which possess intense absorbance in the near-infrared region, could employed as useful photothermal agents for various disease treatments, such as cancer, bacterial infection therapy, and neurodegenerative disease. Moreover, conjugated-polymer-based nanomaterials can be easily combined with other imaging agents and drugs to construct multifunctional nanomaterials for cascading stimuli-responsiveness with precise medical treatment and enhanced therapy efficacy. Here, we mainly put attention on the recent advances of conjugated-polymer-based nanoparticles for photothermal therapy. First, we briefly summarized the mechanism of photothermal conversion of conjugated polymers and the relevant modified methods to improve their photothermal conversion efficiency. Second, we discussed the application of conjugated polymers in photothermal therapy as well as the strategies for developing conjugated-polymer-based nanomaterials with a targeted ability and an enhanced accumulation effect on the tumor region for cancer therapy. Moreover, further challenges and perspectives were also discussed for designing efficient conjugated-polymer-based nanosystems for photothermally assisted therapies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conjugated-Polymer-Based Nanomaterials for Photothermal Therapy

Wang

Meng

Song

et al. 2020

ACS Appl. Polym. Mater.

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“…Arduous multistep synthetic procedures, scalability, and a detailed understanding of structure−function−property relationships remain a limiting factor in the development of CPEbased materials and sensors. 13,21 This motivated our investigation of molecular design strategies that afford facile and rapid access to diverse CPEs applied in the context of current sensing platforms. 22−24 Our molecular design begins with poly[2,7-(9,9-di(pent-4-en-1-yl)fluorene)-alt-ethynyl] (P1), which incorporates pendant pentene substituents at the fluorene bridgehead that provide sufficient solubility of the polymer in organic solvents and allow subsequent functionalization using thiol−ene click chemistry.…”

mentioning

confidence: 99%

“…Arduous multistep synthetic procedures, scalability, and a detailed understanding of structure–function–property relationships remain a limiting factor in the development of CPE-based materials and sensors. , This motivated our investigation of molecular design strategies that afford facile and rapid access to diverse CPEs applied in the context of current sensing platforms. − Our molecular design begins with poly[2,7-(9,9-di(pent-4-en-1-yl)fluorene)- alt -ethynyl] ( P1 ), which incorporates pendant pentene substituents at the fluorene bridgehead that provide sufficient solubility of the polymer in organic solvents and allow subsequent functionalization using thiol–ene click chemistry. , Integration of the ethynyl structural units into poly[2,7-(9,9-di(pentyl-5-(3-sulfopropyl)thio)fluorene)- alt -ethynyl] ( P2 ) was hypothesized to improve assay sensitivity through enhanced backbone rigidity and planarity, which leads to extension of the exciton diffusion length and increases in the intrinsic tendency of the CPE to aggregate in water …”

mentioning

confidence: 99%

Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater

Williams

Tropp

Crater

et al. 2019

ACS Appl. Polym. Mater.

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The evolution of conjugated polyelectrolytes (CPEs) that transduce analyte−receptor interactions into detectable fluorescent responses in complex aqueous environments is predicated on advancements in molecular design and improved synthetic accessibility. Here, we demonstrate a simple postpolymerization modification protocol, based on thiol−ene click chemistry, that results in the rapid installation of sodium sulfate terminated side-chains to a poly(fluorene-co-ethynyl) scaffold. The fluorescence of the resulting water-soluble CPE is quenched by Fe 3+ , dequenched selectively by pyrophosphate (PPi), and accurately quantifies PPi within ±6 nM in artificial seawater. The broad utility of thiol−ene click chemistry should offer the straightforward integration of diverse sensing elements.

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“…Advances in the development of chemistry and material science boomed the preparation of CPEs via conjugated backbone or side chain modification . Generally, synthesis of CPEs is accessible either by postionization of preprepared polymers − or directly by polymerization between ionic monomers. − Both strategies have their merits and limitations.…”

mentioning

confidence: 99%

A Facile Strategy toward Conjugated Polyelectrolyte with Oligopeptide as Pendants for Biological Applications

Liu

Feng

Geng

et al. 2013

ACS Appl. Mater. Interfaces

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We report a facile yet efficient strategy to synthesize biofunctionalized conjugated polyelectrolyte using click reaction between an amphiphilic oligopeptide (R10) and organic soluble polyfluorene (PF) as an example. PF-R10 shows the absorption and emission maxima at ~380 and ~430 nm in water, respectively. In addition, it exhibits enhanced fluorescence in acidic circumstance as compared to that in neutral environment because of reduced aggregation, which is confirmed by laser light scattering and atomic force microscopy studies. In view of the penetration property of the grafted R10 peptide, PF-R10 shows excellent cell uptake and labeling ability in cellular imaging.

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Design and Synthesis of Conjugated Polyelectrolytes

Cited by 6 publications

References 125 publications

Conjugated-Polymer-Based Nanomaterials for Photothermal Therapy

Conjugated-Polymer-Based Nanomaterials for Photothermal Therapy

Thiol–Ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-per-Billion Pyrophosphate Detection in Seawater

A Facile Strategy toward Conjugated Polyelectrolyte with Oligopeptide as Pendants for Biological Applications

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