Design and synthesis of biquinolone–isoniazid hybrids as a new class of antitubercular and antimicrobial agents

Novel 1,3,4-oxadiazole motifs bearing a quinoline nucleus: synthesis, characterization and biological evaluation of their antimicrobial, antitubercular, antimalarial and cytotoxic activities

“…The in vitro antimicrobial screening of targeted compounds 8al at minimal inhibitory concentration (MIC) in millimolar (mM) were carried out by broth micro dilution method according to National Committee for Clinical Laboratory Standards (NCCLS) [37][38][39] Table 3.…”

Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: assessment of their antimicrobial, antituberculosis and antioxidant activity

“…Thus, in view of the biological significance of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione, a modification on the 1-position of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione by 3-methyl-5-phenoxy-1-phenyl-1H-pyrazole was undertaken to check whether it brings significant changes in the bioactivities of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives. As a part of our current study in developing new antimicrobial agents via combination of two therapeutically active moieties [22][23][24][25], we report herein the C. B. Sangani et al preparation 1H-pyrazolo[1,2-b]phthalazine-5,10-dione 4a-p derivatives by an MCR approach.…”

“…In continuation of our interest on synthesizing biologically potent antimicrobials [22][23][24][25], we report herein a new series of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives (4a-p) via one-pot, three-component base-catalyzed cyclo condensation reaction of 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde (1a-d), malononitrile or ethyl cyanoacetate (2a-b) and 2,3-dihydro-1,4-phthalazinedione (3a-b) in ethanol containing eco friendly base NaOH in good to excellent yields (Scheme 1). The required starting material, 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde was prepared by using the procedure in the literature [26].…”

Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups

“…In a long period of time, the quinoline terminal group is found in a large variety of natural compounds and also chemically mediates diverse bioactivities. [2][3][4][5][6][7][8] Yet, no one can ignore the important role of pyridine as an imperative heterocyclic for its countless derivatives and antimicrobial activity. 9 Moreover, multicomponent reactions were employed as a powerful tool to synthesize diverse and complex heterocyclic compounds due to their advantages of the intrinsic atom economy, simpler procedures, structural diversity, and reduced waste.…”