Design and Synthesis of Antimicrobial Active (E)‐(3‐(Substituted‐styryl)‐7H‐furo[2,3‐f]chromen‐2‐yl)(phenyl)methanone Derivatives and Their In Silico Molecular Docking Studies

Abstract

Nine new (E)‐(3‐(substituted‐styryl)‐7H‐furo[2,3‐f]chromen‐2‐yl)(phenyl)methanone derivatives, 7(a–i), with an efficient microwave‐assisted synthetic method was achieved by reacting with (E)‐3‐(aryl)‐1‐(5‐hydroxy‐2H‐chromen‐6‐yl)prop‐2‐en‐1‐ones and 2‐bromo‐1‐(4‐bromophenyl)ethanone. The microwave irradiation method was found to be best with high yields and with shorter reaction times compared with the conventional method. All the new products structural assignments were confirmed by spectral data like FTIR, 1H NMR, 13C NMR, ESI MS, and analytical data. Moreover, these newly synthesized compounds were tested in vitro for their antimicrobial activity against various bacterial and fungal strains. Some of these new chromen derivatives like 7b, 7c, and 7d exhibits good antibacterial and antifungal activities. Furthermore, these biological evolution results were a good correlation with molecular docking studies performed based on their computational DFT minimized structures exhibited high binding energies.

Synthesis of Imidazo[1,2‐b]pyridazine Scaffold Based Amide Derivatives as Potential Inhibitors for Bacterial Activity

“…Later, the residue obtained under vacuum was washed with water and filtered to yield 4, (4.9 g, 96 %) as a pale yellow solid. m. p. 140 -142 °C; [34,35] of Acids (5 and 6) The lithium hydroxide (LiOH) (3.0 equiv.) was added to the alkyl ester (3 and 4) (1.0 equiv.)…”

Michael addition-driven synthesis of cytotoxic palladium(ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity throughin vitroandin vivostudies

“…20 The benzo- γ -pyrone nucleus and its derivatives (flavones, chromones and chromanones) have been reported to exhibit remarkable biological properties via enzymatic inhibition toward different systems such as oxidoreductases, acetylcholinesterase, kinases, tyrosinases and cyclooxygenases. Besides, chromanone derivatives have been used as antiproliferative, 21,22 antioxidant, neuroprotective, 23 antifungal, 24 antimicrobial, 25,26 DNA binding, 27 antiallergic 28 and pesticidal agents. 29 Chromanones have been designed and demonstrated to have extremely potent inhibitory activity against HIV-1 replication.…”