Design and synthesis of an AIE-active polymeric H₂S-donor with capacity for self-tracking

Abstract

Poly(3-formyl-4-hydroxybenzyl methacrylate) (PFHMA) was reacted sequentially with PEG-ONH2, hydrazine and S-benzoylthiohydroxylamine to yield a self-fluorescent polymeric H2S-donor.

Supramolecular Nanostructures with Tunable Donor Loading for Controlled H2S Release

“…H 2 S release from these PHDCs was triggered by Cys, which we and others use commonly to trigger release of H 2 S from SATO-based materials. ,,, In order to eliminate the false response from the electrochemical probe generated by Cys, we used a specially made vial, reported previously, to evaluate PHDC release profiles. In these experiments, the releasing solution was loaded into the inner well of the vial; next, the well was sealed with a gas-permeable membrane (Figure S4).…”

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

“…N -(benzoylthio)benzamides developed by Xian et al [ 82 ] undergo a thioester exchange reaction to form N-SH intermediates, which further react with these compounds to produce H 2 S. S -aroylthiooximes (SATOs) developed by Matson et al [ 83 ] could react with Cys-containing compounds to form thiooxime intermediates that further react with these compounds to generate H 2 S. The H 2 S releasing profile of the above two donors could be regulated by tuning the substituents of donor aromatic rings. Furthermore, thiooxime formation reaction could be conducted at mild condition with high efficiency, thus SATOs have been utilized to establish polymeric H 2 S donors through postpolymerization approaches [ 28 , 73 ]. Naturally occurring polysulfides, represented by diallyl trisulfide (DATS), undergo a thiol-promoted cleavage of polysulfide bond and form hydrosulfide intermediates, which further react with thiol containing compounds to produce H 2 S [ 84 ].…”

Recent Advances on Fabrication of Polymeric Composites Based on Multicomponent Reactions for Bioimaging and Environmental Pollutant Removal

“…[ 127–130 ] Using novel strategies to prepare polymer nanoparticles with unique structures and desirable properties has potential theory significance and industrial application. [ 131,132 ] To our knowledge, different covalent methods such as Schiff base reaction, [ 133 ] emulsion polymerization, [ 32 ] ring‐opening reaction, [ 129 ] and free radical polymerization [ 134 ] have been widely studied to produce desirable AIE polymers with different functional groups in the last few years. Tandem polymerizations, featured with high creation efficiency and convenience, have proved their potential in preparation of macromolecules with π‐conjugated structures in a one‐step way.…”