Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor

Wren, Stephen P.; Piletsky, Sergey A.; Karim, Kal; Gascoine, Paul S.; Lacey, R. W.; Sun, Tao; Grattan, K. T. V.

doi:10.1117/12.2059278

Cited by 1 publication

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“…Rational design studies have allowed the engineering of two probes discussed, derived from 3, that display enhanced sensitivity for the detection of Cocaine, over that seen in earlier generation of probes. [16]- [18] This work builds on but develops in a new direction from that reported earlier by the authors [19] by outlining a rapid method that helps to distinguish between the drug and illicit substances and legal impurities. It has been shown that detection of Cocaine is possible even in the presence of strong fluorescence interference.…”

Section: Discussionmentioning

confidence: 91%

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Computational Design and Fabrication of Optical Fibre Fluorescent Chemical Probes for the Detection of Cocaine

Wren

Piletsky

Karim

et al. 2015

J. Lightwave Technol.

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Abstract-A rationally designed fluorophore has been developed and has been incorporated into molecularly imprinted polymers, as the basis of the design of a sensor. Its use has allowed the fabrication of two different designs of fibre-optic chemical probes using an approach based on the change of the emitted fluorescence being related to the concentration of the desired species that was present. A high sensitivity to the drug Cocaine was achieved with each of the probes, showing positive changes in the fluorescence signal achieved in response to 1-100 μM solutions of the drug, in solution in aqueous acetonitrile. High sensitivity for Cocaine over a range of compounds was demonstrated for one of the probes (probe X) and detection of the drug is possible even in the presence of strong fluorescence interference. The work has also shown that probes of this type do not need to be discarded when used: re-use of probe X is possible using a straightforward washing procedure and the calibration performance was maintained. Permanent repository linkIndex Terms-Chemical probe, Cocaine probe, fluorescence, molecular imprinted polymer (MIP), optical fibre.

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Section: Discussionmentioning

confidence: 91%

“…Two different probe designs, labelled X and Y, are discussed and their performance has been evaluated and extended from our prior work. [19] A detailed evaluation of the selectivity of probe X is also reported.…”

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confidence: 99%