Design and Synthesis of a Novel Peptidomimetic Inhibitor of Caspase-31

Zhang, J; Liu, L; Guo, Yutong; Yang, Jae Wook; Li, W; Zhong, Dafang; Wang, J

doi:10.1016/s1005-9040(06)60082-2

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…A variety of factors can result in quenching. These include inner-filter effect of fluorescence [10], fluorescence resonance energy transfer [11] and charge transfer [12]. We think the quenching mechanism of R6G in the system of Fe 3+ -KI-R6G is charge transfer.…”

Section: Resultsmentioning

confidence: 98%

<b>DETERMINATION OF IRON IN CHINESE HERBAL MEDICINE BASED ON THE FLUORESCENCE QUENCHING OF RHODAMINE 6G</b>

Wang¹,

Lü²,

Yang

2009

Bull. Chem. Soc. Eth.

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A fluorescence quenching method was developed for determination of Fe 3+ with rhodamine 6G as fluorescent reagent. Fe 3+ reacting with KI in diluted sulfuric acid produced I3anion which reacted subsequently with rhodamine 6G to form a non-fluorescence compound. As a result, the compound quenched the fluorescence intensity of the system. The fluorescence intensity decreased linearly with the Fe 3+ concentration in the range from 20 to 200 µg/L. The detection limit was 8.3 µg/L. This method has been applied to determine the iron in Chinese herbal medicine with satisfactory results.

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Section: Resultsmentioning

confidence: 98%

<b>DETERMINATION OF IRON IN CHINESE HERBAL MEDICINE BASED ON THE FLUORESCENCE QUENCHING OF RHODAMINE 6G</b>

Wang¹,

Lü²,

Yang

2009

Bull. Chem. Soc. Eth.

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“…Caspase-3 is an attractive target for therapeutic intervention due to have functions in apoptosis, mediating apoptotic cascade from the intrinsic and extrinsic activation pathways. Zhang et al [178] designed a novel peptidomimetic inhibitor of caspase-3, which had the properties of a reversible inhibitor, while the P1 site at the C-terminal remains and only Lamino acid has been replaced by D-amino acid. Thrombosisrelated disorders such as deep vein thrombosis, pulmonary embolism, and thromboembolic stroke remain a major cause of morbidity worldwide.…”

Section: Other Applicationsmentioning

confidence: 99%

Peptidomimetics and their Applications in Antifungal Drug Design

Moradi¹,

Soltani²,

Ansari³

et al. 2009

AIAMC

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The antimicrobial peptides represent diverse structures for drug design. They have been looked at as potential sources of new antimicrobial drugs to combat the increasing threat posed by multiple drug resistant microorganisms. Unfortunately, peptides themselves provide inferior drug candidates because of their low oral bioavailability, potential immunogenicity, poor in vivo metabolic stability, high molecular weight and most importantly being exposed by enzymes like proteases. Recent efforts to resolve disadvantageous peptide characteristics, and thus generating practical pharmaceutical therapies, have focused on the creation of non-natural peptide mimetics. Peptidomimetic molecules may have reduced immunogenicity and improved bioavailability relative to peptide analogues. Also the artificial backbone makes most peptidomimetics resistant to degradative enzymes thus increasing the stability of peptidomimetic drugs in the body. In this article, after introducing antifungal peptides, benefits and limitations, and peptidomemetics usage are discussed and applications in drug discovery process and antifungal research will be presented.

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“…Among these polymerizations, RAFT process has caused the extensive interest because of its gentle polymerized condition and low molecular weight distribution. The typical RAFT process is known as the reversible chain transfer of propagating radicals to thiocarbonylthio compounds such as dithioesters [4], trithiocarbonates [5] and xanthates [6]. Isopropylxanthic disulfide (DIP), a conventional tuber vulcanization accelerator [7], is a bifunctional xanthogenic derivative.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Self-Assemble Behavior of Block Copolymerization of Vinyl Acetate and N-Vinylacetamide

Shi

Dong

et al. 2013

AMR

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Polymerizations of VAc was carried out using AIBN as the initiator and DIP as the MADIX agent precursor. Then, block copolymer PVAc-b-PNVA had been synthesized by RAFT radical polymerization in the presence of PVAc-DIP as macro CTA. The length of blocks could be tuned by changing the molar ratio of NVA and VAc. Block copolymer PVAc-b-PNVA self-assembled into micelles in solution, and underwent microphase separation in bulk state.

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Design and Synthesis of a Novel Peptidomimetic Inhibitor of Caspase-31

Cited by 6 publications

References 9 publications

<b>DETERMINATION OF IRON IN CHINESE HERBAL MEDICINE BASED ON THE FLUORESCENCE QUENCHING OF RHODAMINE 6G</b>

<b>DETERMINATION OF IRON IN CHINESE HERBAL MEDICINE BASED ON THE FLUORESCENCE QUENCHING OF RHODAMINE 6G</b>

Peptidomimetics and their Applications in Antifungal Drug Design

Synthesis and Self-Assemble Behavior of Block Copolymerization of Vinyl Acetate and N-Vinylacetamide

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