Design and synthesis of a ratiometric photoacoustic imaging probe activated by selenol for visual monitoring of pathological progression of autoimmune hepatitis

Zhang, Chaobang; Qiu, Zhidong; Zhang, Liangliang; Pang, Qiufang; Yang, Zhengming; Qin, Jiang-Ke; Liang, Hong; Zhao, Shulin

doi:10.1039/d0sc06573k

Cited by 25 publications

(30 citation statements)

References 34 publications

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“…For example, selenol‐responsive bis(2‐hydroxyethyl) disulfide was covalently linked to the intermediate active site of NIR cyanine dyes used to detect selenol in autoimmune hepatitis. [ 190 ] Yin et al substituted the active chlorine in IR806 with pyridine dithioethylamine, a GSH‐responsive molecule. In the presence of GSH, the disulfide bond was cleaved and reduced to sulfhydryl groups, which then replaced the secondary amine to form thio‐substituted IR806.…”

Section: “Turn‐on” Pa Imaging Probesmentioning

confidence: 99%

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Zeng

Dou

et al. 2022

Advanced Science

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Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificity of PA imaging and to offer diagnostic information for illnesses. The existing PA contrast agents are categorized into two groups in this review: “always‐on” and “turn‐on,” based on their ability to be triggered by target molecules. The present state of these probes, their merits and limitations, and their future development, is explored.

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Section: “Turn‐on” Pa Imaging Probesmentioning

confidence: 99%

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Zeng

Dou

et al. 2022

Advanced Science

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“…A selenol‐responsive photoacustic (PA) imaging probe for the visual monitoring of pathological progression of autoimmune hepatitis (AIH) was very recently developed by Zhang et al [120] . The functioning of such a probe exploits the nucleophilicity of selenols ( i. e .…”

Section: Synthetic Applications Of Selenolsmentioning

confidence: 99%

“…AIH‐specific antibodies, such as those against soluble liver antigen (SLA) and liver pancreas antigen (LP), are commonly used as diagnostic markers and are also among the most important Sec synthases. In this context, a probe for monitoring the selenols concentration may provide new tools to study the progression of AIH [120] …”

Section: Synthetic Applications Of Selenolsmentioning

confidence: 99%

“…[118] A gold nanorod fluorescent sensor with antibacterial activity, capable to selectively recognise Escherichia coli was also developed exploiting the reactivity of sulfamide bonds of the probe with the selenol moieties of bacterial selenoproteins. [119] A selenol-responsive photoacustic (PA) imaging probe for the visual monitoring of pathological progression of autoimmune hepatitis (AIH) was very recently developed by Zhang et al [120] The functioning of such a probe exploits the nucleophilicity of selenols (i. e. Sec, or its corresponding selenolate anion) and the rapid response of bis(2-hydroxyethyl)disulfide to selenols, with high specificity for Sec and GSeH (selenoglutathione). The near-infrared cyanine dye was employed as the scaffold to design the PA probe with minimised background interferences.…”

Section: Scheme 42mentioning

confidence: 99%

“…In this context, a probe for monitoring the selenols concentration may provide new tools to study the progression of AIH. [120] On the other hand, selenol chemistry can also be exploited for the detection of sulfur-containing systems. Gao et al developed a new selenium-containing near-infrared fluorescent probe for imaging of sulfane sulfur changes under hypoxic stress in cells and in vivo.…”

Section: Scheme 42mentioning

confidence: 99%

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Synthesis and Applications of Organic Selenols

Tanini

Capperucci

2021

Adv Synth Catal

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The synthesis and the study of organoselenium compounds have received much attention over the past decades. Selenium-containing organic molecules are widely used in organic synthesis, materials science, and medicinal chemistry. Selenium -and more specifically the amino acid selenocysteine, bearing a selenol (SeH) moiety -is present in at least 25 human protein families, whose biological functions have not been completely identified. Amongst the variety of organoselenium compounds, selenols are a versatile class of molecules easily undergoing a broad array of useful transformations. Because of the unique properties of the SeH group, selenol chemistry has important applications in chemical sciences, spanning from organic synthesis to materials chemistry and biology. This review summarises currently available methodologies for the synthesis of selenols and highlights applications of selenols in chemical sciences and biology. Conclusions and Outlook 5.1. Safety Measures

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Visual Investigation of Tumor‐Promoting Fibronectin Potentiated by Obesity in Pancreatic Ductal Adenocarcinoma Using an MR/NIRF Dual‐Modality Dendrimer Nanoprobe

Liu

Chang

et al. 2023

Adv Healthcare Materials

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by dense stroma. Obesity is an important metabolic factor that greatly increases PDAC risk and mortality, worsens progression and leads to poor chemotherapeutic outcomes. With omics analysis, magnetic resonance and near‐infrared fluorescence (MR/NIRF) dual‐modality imaging and molecular functional verification, obesity as an important risk factor is proved to modulate the extracellular matrix (ECM) components and enhance Fibronectin (FN) infiltration in the PDAC stroma, that promotes tumor progression and worsens response to chemotherapy by reducing drug delivery. In the study, to visually evaluate FN in vivo and guide PDAC therapy, an FN‐targeted nanoprobe, NP‐CREKA, is synthesized by conjugating gadolinium chelates, NIR797 and fluorescein isothiocyanate to a polyamidoamine dendrimer functionalized with targeting peptides. A dual‐modality strategy combining MR and NIRF imaging is applied, allowing effective visualization of FN in orthotopic PDAC with high spatial resolution, ideal sensitivity and excellent penetrability, especially in obese mice. In conclusion, the findings provide new insights into the potential of FN as an ideal target for therapeutic evaluation and improving treatment efficacy in PDAC, hopefully improving the specific management of PDAC in lean and obese hosts.

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Design and synthesis of a ratiometric photoacoustic imaging probe activated by selenol for visual monitoring of pathological progression of autoimmune hepatitis

Abstract: Photoacoustic (PA) imaging with both the high contrast of optical imaging and the high spatial resolution of ultrasound imaging, has been regarded as a robust biomedical imaging technique. Autoimmune hepatitis...

Cited by 25 publications

References 34 publications

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Synthesis and Applications of Organic Selenols

Visual Investigation of Tumor‐Promoting Fibronectin Potentiated by Obesity in Pancreatic Ductal Adenocarcinoma Using an MR/NIRF Dual‐Modality Dendrimer Nanoprobe

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