Design and Synthesis of 7-Chloro-3-Substituted Quinazolin-4(3h)-Ones as Potential Anti-Inflammatory and Analgesic Agents

Abstract

In our effort to identify potent anti-inflammatory and analgesic agents a number of 7-chloro-3-substituted-2-phenylquinazolin-4(3H)-ones have been synthesized starting from 4-chloro anthranilic acid. Docking analysis of the quinazolinone derivatives were done with COX-II protein which was carried out by means of the AutoDock program. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). The synthesized compounds were tested for their analgesic activity by tail-flick method and anti-inflammatory activity by carrageenan induced rat paw oedema method. Preliminary evaluation of the anti-inflammatory and analgesic properties of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diclofenac standard.