Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents

Hypolipidemic, Hypoglycemic and Anti-oxidant Activities of Flower Extracts of <i>Allamanda Violacea</i> A. DC (Apocynaceae)

“…The test group was administered a suspension of the extract orally (formulated in 1 % gum acacia) at a dose of 100 mg/kg while the control group received an equal amount of 1 % gum acacia (400 μl) only. A sucrose load (10 g/kg) was given to the animals in both groups orally 30 min later, to evaluate the decrease in the postprandiol rise in blood glucose [15]. The blood glucose profile of the rats was determined at 30, 60, 90 and 120 min after extract/vehicle administration with a glucometer.…”

“…The blood glucose profile of the rats was determined at 30, 60, 90 and 120 min after extract/vehicle administration with a glucometer. Food, but not water, was withheld from the animals during the course of experimentation [15].…”

Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions

“…In addition, they can be used as useful drugs for the treatment of Alzheimer's disease [6]. Recently, Kumar et al showed that some compounds with quinolone skeleton act as a lead in the antidiabetic discovery [7], with effects such as glycologenphosphorylase inhibitors [8][9][10][11][12], or as lipid lowering agent [13] and also for the treatment of metabolic disorder. Also, a number of quinolones are useful in industry as pigments [14].…”

“…There are several methods available for the synthesis of quinolinones, for example: 1) the reaction of aromatic aldehydes, dimedone and 3-amino-5-methylpyrazolevia traditional heating in ethanol [15] or in water, 2) the reaction of Schiff base derivatives and dimedone in the presence of TEBAC as catalyst [16]; 3) the condensation reaction of Baylis-Hillman adductive products with cyclic enamine in n-buthanol at reflux conditions [17], and condensation of chalcones with dimedone and ammonium acetate in the presence of PTSA at reflux condition [7]. However, these methods are still not satisfactory in view of using catalyst, organic solvent waste, harsh reaction conditions, long reaction time and operational complexity.…”

A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid

“…The polyhydroquinoline moiety is a fertile source of biologically and pharmacologically important molecules such as vasodilator, bronchodilator, anti-atherosclerotic, hepto-protective, anti-tumor, anti-mutagenic, geroprotective, anti-diabetic agents, HIV protease inhibition and most importantly as calcium channel blockers. [8][9][10][11][12][13][14][15] All mentioned cases demonstrate clearly the remarkable potential of the polyhydroquinoline derivatives as a source of valuable drugs. 16,17 In continuation of our investigation on the use of nano-g-Fe 2 O 3 -SO 3 H as catalyst for MCRs and our interest in synthesis of heterocycles containing a nitrogen atom, 18,19 we report an efficient and facile synthesis of hexahydroquinolines under solvent-free conditions (Scheme 1).…”