Design and study of the potential of crosslinked cationic polymers as drug delivery systems for dermal application

Abstract

Crosslinked carriers based on cationic monomer [2-(acryloyloxy)ethyl]trimethylammonium chloride or 2-(dimethylamino)ethyl methacrylate were developed and investigated as new platform for ibuprofen transdermal delivery. Series of networks of varied composition and structure were synthesized and characterized by FTIR spectroscopy and following swelling kinetics in different solvents. Dermal safety tests to examine the skin irritation and sensitization potential of the network films were performed in vivo. Chosen network compositions were loaded with ibuprofen by swelling in its ethanol solution. The structures of the drug carriers were investigated by scanning electron microscopy. Ibuprofen release from the developed drug delivery systems was followed in phosphate buffer solution at 37 8C. The investigation proved the feasibility of the developed cationic copolymer networks as effective platforms with modified ibuprofen release for potential dermal application.

Research Progress on Typical Quaternary Ammonium Salt Polymers

“…The researchers thought that cationic polymers should never be considered as an inert, biocompatible component of biotechnological applications aimed to interact with living systems. In 2018, Bistra et al [144] synthesized reticular PDAC on a 1 mm glass sheet by adding crosslinking agents and used the reticular PDAC as a crosslinking carrier for ibuprofen administration in vivo for a skin safety test. It was found that ibuprofen was released from the drug delivery system in a phosphate buffer solution at 37~38 • C, demonstrating the feasibility of cationic cross-linked polymers as effective carriers for the sustained release of ibuprofen.…”

Conceptualization and Investigation of Multicomponent Polymer Networks as Prospective Corticosteroid Carriers

“…Hydrogels are advantageous delivery systems for hydrophilic drugs because dissolved drugs could be included in the swollen cross-linked polymer matrix [ 29 , 30 , 31 ]. A variety of network structures could be used for the development of hydrogels suitable for dermal drug delivery applications, including copolymer architectures [ 38 , 39 , 40 ] and interpenetrating (IPN) and semi-interpenetrating networks [ 41 , 42 , 43 ]. A high swelling capacity in water and in body liquids of the networks, which reduces the irritancy of the carrier, is of prime importance, along with the general requirements for biocompatibility and non-toxicity.…”