Design and Simulation of an Autonomous Molecular Mechanism Using Spatially Localized DNA Computation

Wang, Yue; Wang, Luhui; Hu, Wenxiao; Qian, Mengyao; Dong, Yafei

doi:10.1007/s12539-023-00551-5

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Organic nanomaterials encompass polymer nanomaterials and bioactive nanomaterials such as nucleic acids, proteins, and peptides. [118][119][120][121]…”

Section: Organic Nanomaterialsmentioning

confidence: 99%

Nano‐Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

Liu,

Du,

Chen

et al. 2024

Macromol. Rapid Commun.

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Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing their role in minimally invasive therapeutic delivery, tissue repair, and regeneration. The recent emergence of nanomaterials has ushered in a revolutionary transformation in the biomedical field, which demonstrates tremendous potential in targeted therapies, biological imaging, and disease diagnostics. Consequently, the integration of advanced nanotechnology promises to trigger a new revolution in the realm of hydrogels. HMs loaded with nanomaterials combine the advantages of both hydrogels and nanomaterials, which enables multifaceted functionalities such as efficient drug delivery, sustained release, targeted therapy, biological lubrication, biochemical detection, medical imaging, biosensing monitoring, and micro‐robotics. Here, this review comprehensively expounds upon commonly used nanomaterials and their classifications. Then, it provides comprehensive insights into the raw materials and preparation methods of HMs. Besides, the common strategies employed to achieve nano‐micron combinations are summarized, and the latest applications of these advanced nano‐micron combined HMs in the biomedical field are elucidated. Finally, valuable insights into the future design and development of nano‐micron combined HMs are provided.

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“…Organic nanomaterials encompass polymer nanomaterials and bioactive nanomaterials such as nucleic acids, proteins, and peptides. [118][119][120][121]…”

Section: Organic Nanomaterialsmentioning

confidence: 99%

Nano‐Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

Liu,

Du,

Chen

et al. 2024

Macromol. Rapid Commun.

View full text Add to dashboard Cite

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“…Artificial nanozymes also have the advantages of high yield with low cost and a long storage time without being readily degraded. [14,15] Therefore, it is crucial for future demand to develop chiral encoded artificial nanozymes with enhanced selectivity. Chiral nanomaterials modified by chiral ligands possess distinct recognition abilities toward chiral enantiomers and show potential application for enantioselective catalysis.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Chiral Nanomaterials with Selective Catalysis Activity

Cao,

Yang,

Kim

et al. 2024

Advanced Science

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Chiral nanomaterials with unique chiral configurations and biocompatible ligands have been booming over the past decade for their interesting chiroptical effect, unique catalytical activity, and related bioapplications. The catalytic activity and selectivity of chiral nanomaterials have emerged as important topics, that can be potentially controlled and optimized by the rational biochemical design of nanomaterials. In this review, chiral nanomaterials synthesis, composition, and catalytic performances of different biohybrid chiral nanomaterials are discussed. The construction of chiral nanomaterials with multiscale chiral geometries along with the underlying principles for enhancing chiroptical responses are highlighted. Various biochemical approaches to regulate the selectivity and catalytic activity of chiral nanomaterials for biocatalysis are also summarized. Furthermore, attention is paid to specific chiral ligands, materials compositions, structure characteristics, and so on for introducing selective catalytic activities of representative chiral nanomaterials, with emphasis on substrates including small molecules, biological macromolecule, and in‐site catalysis in living systems. Promising progress has also been emphasized in chiral nanomaterials featuring structural versatility and improved chiral responses that gave rise to unprecedented chances to utilize light for biocatalytic applications. In summary, the challenges, future trends, and prospects associated with chiral nanomaterials for catalysis are comprehensively proposed.

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“…[10] Furthermore, chemotherapy, known for its lack of specificity, poses challenges within the delicate visual system due to its profound side effects and the development of drug resistance over prolonged use. [11][12][13] In response to these challenges, innovative techniques such as Chemodynamic Therapy (CDT), [14][15][16] Photothermal Therapy (PTT), [17,18] and Photodynamic Therapy (PDT) [19,20] have emerged to enhance the efficiency of cancer treatment. Notably, PTT can be triggered by low-energy lasers, including near-infrared (NIR) lasers, which convert light into heat to eliminate cancer cells.…”

Section: Introductionmentioning

confidence: 99%

AIBI Modified Mesoporous Copper Sulfide Nanocomposites for Efficient Non‐Oxygen Dependent Free Radicals‐Assisted Photothermal Therapy in Uveal Melanoma

Huang,

Kong,

Zhang

et al. 2024

Small

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Uveal melanoma (UM) is an ocular cancer predominantly affecting adults, characterized by challenging diagnostic outcomes. This research endeavors to develop an innovative multifunctional nanocomposite system sensitive to near‐infrared (NIR) radiation, serving as both a non‐oxygen free‐radical generator and a photothermal agent. The designed system combines azobis isobutyl imidazoline hydrochloride (AIBI) with mesoporous copper sulfide (MCuS) nanoparticles. MCuS harnesses NIR laser energy to induce photothermal therapy, converting light energy into heat to destroy cancer cells. Simultaneously, AIBI is activated by the NIR laser to produce alkyl radicals, which induce DNA damage in remaining cancer cells. This distinctive feature equips the designed system to selectively eliminate cancers in the hypoxic tumor microenvironment. MCuS is also beneficial to scavenge the overexpressed glutathione (GSH) in the tumor microenvironment. GSH generally consumes free radicals and hiders the PDT effect. To enhance control over AIBI release in cancer cells, 1‐tetradecyl alcohol (TD), a phase‐changing material, is introduced onto the surface of MCuS nanoparticles to create the final AMPT nanoparticle system. In vitro and in vivo experiments confirm the remarkable anti‐tumor efficacy of AMPT. Notably, the study introduces an orthotopic tumor model for UM, demonstrating the feasibility of precise and effective targeted treatment within the ocular system.

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Design and Simulation of an Autonomous Molecular Mechanism Using Spatially Localized DNA Computation

Cited by 3 publications

References 33 publications

Nano‐Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

Nano‐Micron Combined Hydrogel Microspheres: Novel Answer for Minimal Invasive Biomedical Applications

Biomimetic Chiral Nanomaterials with Selective Catalysis Activity

AIBI Modified Mesoporous Copper Sulfide Nanocomposites for Efficient Non‐Oxygen Dependent Free Radicals‐Assisted Photothermal Therapy in Uveal Melanoma

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