Design and release characteristics of sustained release tablet containing metformin HCl

Basak, S. C.; Kumar, K Senthil; Ramalingam, Mani

doi:10.1590/s1516-93322008000300018

Cited by 55 publications

(37 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To gain an idea of the release properties of the generated materials, the drug release profiles were plotted against zero-order, first-order, Higuchi, Hixson-Crowell and Ritger-Peppas models and their R 2 values were compared as is a common practice in the literature [62][63][64][65][66][67][68].…”

Section: Cpt Release Assay By Fluorimetrymentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

View full text Add to dashboard Cite

Aims: Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. Original submitted 16 December 2010; Revised submitted 29 September 2011; Published online 6 March 2012

show abstract

Section: Cpt Release Assay By Fluorimetrymentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The data were fitted to a modified Korsmeyer-Peppas model, 18 where DR is the fractional release at time, t in minutes, k is a rate constant, a is the fraction released in the burst and n gives mechanistic insight. 22 At pH 1 and 12, both a and k are greater than at pH 5 and 9 (Table S1, ESIw). In all cases, n o 0.5, indicating a quasi-Fickian diffusion process.…”

mentioning

confidence: 97%

Porous ‘Ouzo-effect’ silica–ceria composite colloids and their application to aluminium corrosion protection

et al. 2012

View full text Add to dashboard Cite

By exploiting spontaneous emulsification to prepare porous SiO 2 particles, we report the formation of porous CeO 2 @SiO 2 hybrid colloids and their incorporation into a silica-zirconia coating to improve the corrosion protection of aluminium.The ''Ouzo effect'' is probably better known as a drinkers' conundrum than as a technique for the formation of colloidal particles. The careful addition of water to e.g. Pastis, Absinthe, etc. causes the spontaneous emulsification of a metastable droplet phase, driven by the aqueous insolubility of the flavour compound (trans-anethole). Several studies have sought to characterise the underlying process 1 and to use it for the production of polymer particles and capsules.2 As a synthesis method, spontaneous emulsification has the advantage of requiring neither externally applied energy, nor stabilizing or templating species. Using a simple system consisting of water, ethanol, ammonia, hydrochloric acid and silicon alkoxides, porous silica particles were formed.3 However, few other reports use this method to form hard, porous colloidal particles and there have been no reports of their application. This is remarkable given that while porous particles have been developed for many applications (e.g. catalysis, drug delivery, chromatography, corrosion inhibition), almost all of the preparation methods suffer the requirement of templating species, hightemperature syntheses or high shear pre-emulsification. [4][5][6][7] A spontaneous emulsification-based route to form porous materials would be cheap, simple, non-hazardous and therefore warrants further consideration. One way to functionalise the resultant particles (e.g. zeolite or silica) is to adsorb active nanoparticles.8 Such hybrid colloids would have the benefit of easy solution uptake and facile incorporation into e.g. coatings.Here, a spontaneous emulsification process was used to prepare porous silica particles, 3 which are capable of nanoparticle and/or small molecule uptake. Ceria was chosen as the active content, given its known use both in oxidation catalysis 4,9 and in corrosion protection. [10][11][12] Several routes exist to form ceria nanocrystals. 9,13 Here, an adapted precipitation method was employed, 14 due to its simplicity and high yield. Fig. 1a shows the characterization of the ceria particles by XRD. Peaks corresponding to the fluorite ceria structure are clearly noted and marked, with substantial broadening indicating the presence of nano-crystalline grains. The minimum grain size was calculated to be 5.5 nm by the Scherrer equation 15 using shape factor = 0.9, in line with an approximate particle size estimated by TEM (d E 5 nm, Fig. S1, ESIw). TEM images of the silica spheres formed by spontaneous emulsification are shown in Fig. 1b. The sample mainly consisted of polydisperse porous particles with d mean E 200 nm (see ESIw). The dependence on the zeta potential with pH ( Fig. 1c) for the silica and ceria particles showed typical isoelectric points (IEP) at pH 3.2 and pH 8.5, respectively. 16 The BET su...

show abstract

“…The remaining n values are less than 0.5, which indicate the Quasi Fickian diffusion meaning that the drug release mechanism from the Ca-Alg hydrogel is diffusion controlled [9,22,25]. The smaller value of the diffusion exponent may be attributed to the diffusion occurring partially through the matrix swelling with water filled pores [22,26,27]. It is noticed from Table 2 and 3 that both scaling exponents n 1 and n 2 for a given drug and matrix become larger under the presence of applied electric field.…”

Section: Effect Of Crosslinking Ratio and Drugmentioning

confidence: 99%

Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel

Paradee

Sirivat

Niamlang

et al. 2012

J Mater Sci: Mater Med

View full text Add to dashboard Cite

The drug release characteristics of calcium alginate hydrogels, (Ca-Alg), under an electric field assisted transdermal drug delivery system were systematically investigated. The Ca-Alg hydrogels were prepared by the solution-casting using CaCl(2) as a crosslinking agent. The diffusion coefficients and the release mechanism of the anionic model drugs, benzoic acid and tannic acid, and a cationic model drug, folic acid on the Ca-Alg hydrogels were determined and investigated using a modified Franz-Diffusion cell in an MES buffer solution of pH 5.5, at a temperature of 37°C, for 48 h. The influences of the crosslinking ratio, -the mole of the crosslinking agent to the mole of the alginate monomer-mesh size, model drug size, drug charge, electric field strength, and electrode polarity were systematically studied. The drug diffusion coefficient decreased with an increasing crosslinking ratio and drug size for all of the model drugs. The drug diffusion coefficient is precisely controlled by an applied electric field and the electrode polarity depending on the drug charge, suitable for a tailor-made transdermal drug delivery system.

show abstract

Design and release characteristics of sustained release tablet containing metformin HCl

Abstract: Metformin hydrochloride (metformin HCl)

Cited by 55 publications

References 14 publications

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Porous ‘Ouzo-effect’ silica–ceria composite colloids and their application to aluminium corrosion protection

Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel

Contact Info

Product

Resources

About