Design and rationale of a prospective, multi-institutional registry for patients with sinonasal malignancy

Beswick, Daniel M.; Holsinger, F. Christopher; Kaplan, Michael; Fischbein, Nancy J.; Hara, Wendy; Colevas, A. Dimitrios; Le, Quynh‐Thu; Berry, Gerald J.; Hwang, Peter H.

doi:10.1002/lary.25996

Cited by 14 publications

(18 citation statements)

References 22 publications

(32 reference statements)

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“…This investigation of a rare disease was completed using a prospective, multi-institutional approach. 14 Rare diseases are often difficult to study, with challenges stemming from small sample sizes, need for alternatives to randomized trial design, and limited resources, including funding. 19 Studies evaluating SNM treatment outcomes are further challenged by tumor diversity and evolving treatment paradigms.…”

Section: Discussionmentioning

confidence: 99%

Surgical approach is associated with complication rate in sinonasal malignancy: A multicenter study

Beswick

Hwang

Adappa

et al. 2021

Int Forum Allergy Rhinol

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Background: Management of sinonasal malignancy (SNM) often includes surgical resection as part of the multimodality treatment. Treatment-related surgical morbidity can occur, yet risk factors associated with complications in this population have not been sufficiently investigated.Methods: Adult patients with histologically confirmed SNM whose primary treatment included surgical resection were prospectively enrolled into an observational, multi-institutional cohort study from 2015 to 2020. Sociodemographic, disease, and treatment data were collected. Complications assessed included cerebrospinal fluid leak, orbital injury, intracranial injury, diplopia, meningitis, osteoradionecrosis, hospitalization for neutropenia, and subsequent chronic rhinosinusitis. The surgical approach was categorized as endoscopic resection (ER) or open/combined resection (O/CR). Associations between factors and complications were analyzed using Student's t test, Fisher's exact test, and logistic regression modeling.

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Section: Discussionmentioning

confidence: 99%

Surgical approach is associated with complication rate in sinonasal malignancy: A multicenter study

Beswick

Hwang

Adappa

et al. 2021

Int Forum Allergy Rhinol

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“…Many authors in literature conclude similarly that prospective multicentric studies are needed to reach higher patient numbers and improve scientific conclusions. Beswick et al designed a web-based multi-institutional registry for patients with sinonasal malignancies, a webbased, secure database to prospectively collect data in cases diagnosed with sinonasal malignancies [57]. This could be an incitement for further research of similar portals, especially in Europe.…”

Section: Discussionmentioning

confidence: 99%

“…Beswick et al. designed a web-based multi-institutional registry for patients with sinonasal malignancies, a web-based, secure database to prospectively collect data in cases diagnosed with sinonasal malignancies [ 57 ]. This could be an incitement for further research of similar portals, especially in Europe.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal mucosal melanoma: treatment strategies and survival rates for a rare disease entity

Andrianakis

Kiss

Pomberger

et al. 2021

Wien Klin Wochenschr

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Summary Background Sinonasal mucosal melanoma (SNMM) is a rare disease entity comprising 0.4–1.3% of all melanomas. Surgery with free margins has been the primary treatment over decades. Neither the addition of radiotherapy nor chemotherapy could significantly improve outcome rates of this devastating malignancy. This study presents our clinical experience with SNMM over a 19-year period and summarizes the current body of literature on SNMM. Methods This retrospective analysis included 12 patients with SNMM treated from 2001 to 2019 at an academic center. Additionally, a literature review of the last 29 years on treatment and survival data of SNMM was conducted. Results Main initial symptoms were epistaxis and nasal obstruction. Of the patients 9 underwent endoscopic surgery, 6 received adjuvant therapy. 3 patients who did not undergo surgery, received chemoradiotherapy, radiotherapy alone, and chemotherapy alone, respectively. At the time of diagnosis 2 patients had distant metastases and 4 patients developed distant metastases during the course of the disease. Mean overall survival (OS) was 30.6 months, 3‑year and 5‑year OS were 25%, and 18.2%, respectively. Conclusion Unspecific symptoms and hidden anatomic locations lead to delayed diagnosis and increased rates of metastatic dissemination. Distant metastasis is the main treatment failure in SNMM. Surgery with free margins remains the primary treatment for SNMM. Adjuvant radiotherapy might improve local control in individual cases but efficient systemic therapy is needed to improve outcome rates. To evaluate and define more effective targeted treatment options and improve outcome rates, homogeneous data and prospective multicentric analysis are needed.

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“…In recent years, immunologic/targeted therapy based on patients' genetic changes has been gradually applied to patients with mucosal melanoma, and our study also confirmed that the application of immunologic/targeted therapy had a beneficial impact on prognosis. Relevant studies have shown that the phenotypic changes related to MMHN include C-Kit, NRAS, and GNAQ [ 21 – 23 ], which are the targets of some targeted drugs, including vemurafenib, imatinib, and nilotinib [ 24 ]. Tumor-mediated immune tolerance is a focus at present.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities

Lai

Huang

et al. 2021

Radiat Oncol

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Objectives The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide a reference for the individualized treatment of MMHN. Methods We retrospectively reviewed 262 patients with stage III–IVb MMHN treated from March 1986 to November 2018 at our cancer center. Results The median follow-up time was 34.0 months (range 1–262 months). The 5-year overall survival (OS), distant metastasis-free survival (DMFS) and disease-free survival (DFS) probabilities were 37.7%, 30.2%, and 20.3%, respectively. The 5-year OS rates for patients with stage III, stage IVA, and stage IVB MMHN were 67.0%, 24.1% and 8.3%, respectively (P < 0.001). A total of 246 (93.9%) patients received surgery, 149 (56.9%) patients received chemotherapy, and 69 (26.3%) patients received immunologic/targeted therapy. A total of 106 (40.5%) patients were treated with radiotherapy: 9 were treated with preoperative radiotherapy, 93 were treated with postoperative radiotherapy, and 4 were treated with radiotherapy alone. In the multivariate Cox regression analysis, primary tumor site, T stage, and immunologic/targeted therapy were independent factors for OS (all P < 0.05). Irradiation technique, T stage, and N stage were independent prognostic factors for DMFS (all P < 0.05). T stage, N stage, and surgery were independent prognostic factors for DFS (all P < 0.05). Distant metastasis was observed in 107 of 262 patients (40.8%), followed by local [74 (28.2%)] and regional [52 (19.8%)] recurrence. Conclusions The main reason for treatment failure in MMHN is distant metastasis. Immunologic/targeted therapy and surgery are recommended to improve the survival of MMHN. The American Joint Committee on Cancer (AJCC) 8th edition staging system for MMHN does stage this disease effectively.

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Design and rationale of a prospective, multi-institutional registry for patients with sinonasal malignancy

Abstract: 2C Laryngoscope, 126:1977-1980, 2016.

Cited by 14 publications

References 22 publications

Surgical approach is associated with complication rate in sinonasal malignancy: A multicenter study

Surgical approach is associated with complication rate in sinonasal malignancy: A multicenter study

Sinonasal mucosal melanoma: treatment strategies and survival rates for a rare disease entity

Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities

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