Design and rationale for the Myocardial Stem Cell Administration After Acute Myocardial Infarction (MYSTAR) Study: A multicenter, prospective, randomized, single-blind trial comparing early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of nonselected autologous bone marrow cells to patients after acute myocardial infarction

Endoventricular Electromechanical Mapping—The Diagnostic and Therapeutic Utility of the NOGA® XP Cardiac Navigation System

“…Direct intramyocardial delivery is especially well-placed for cell types that are large and adherent (e.g., skeletal myoblasts (SkMs) and mesenchymal stromal cells (MSCs)) and for chronic ischemic disease, such as hibernating myocardium or chronic infarct scar. Safety of catheterbased intramyocardial injection is still undergoing evaluation in acute MI [74], but injections have been performed safely in the preclinical setting [75].…”

Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres

“…These therapies generally involve the injection of a cell suspension, possibly stem cells or genetically modified cells, directly into the targeted location. Although current clinical trials are promising [24], the survival and engraftment of injected cells is often limited [22,25,26], thereby reducing the potential therapeutic effects. Cell survival is impacted by both mechanical injury during the injection process, and also the cellular microenvironment of the implantation site, which may not be ideal for maintaining viability because of the extent of tissue disease or injury, or simply because the cells are introduced to a non-native environment.…”

Geometric modeling and motion analysis of the epicardial surface of the heart

“…A large proportion of these individuals who undergo these examinations are suspected of having coronary artery disease. Thanks to the widespread availability of multi-slice CT scanners [12,13,18], it has become usual clinical practice to first refer these individuals to cardiac CT [10,12]. If the presence of coronary artery disease cannot be excluded with this less invasive imaging modality, conventional X-ray angiograms, which are significantly more invasive, are indicated as a second line of investigation.…”

“…three-dimensional CT data sets and biplane angiograms are at the disposal of the cardiologist. In current clinical practice, the routine analyses of this multimodal imagery focus mainly on the patency of the coronary (epicardial) arteries, in particular, the assessment of the stenoses and on investigations of the calcifications within the arterial walls, especially in regions of haemodynamically relevant stenoses [10,12,16,18].…”