Design and production of gentamicin/dextrans microparticles by supercritical assisted atomisation for the treatment of wound bacterial infections

The Synergistic Antibacterial Mechanism of Gentamicin-Loaded CaCO3 Nanoparticles

“…A broad band around 3,448 cm −1 confirmed the −OH stretching vibration of the absorbed water (Lin et al, 2014). In the spectrum of GS, it exhibited the bands at 1,631 and 1,535 cm −1 (N–H bending vibration bands) (Aquino et al, 2013; Dizaj et al, 2016), 1,130 cm −1 (C–O stretching vibration). The spectrum of CGPs showed most characteristic bands of GS and CCNPs, which indicated the effective loading of drug onto CCNPs.…”

Supercritical fluids applications in nanomedicine

“…It has been successfully used to produce fine particles of several pharmaceuticals and composite microparticles for drug release [60][61][62][63][64]. In this process, the organic solution and SC-CO 2 form an expanded liquid in a saturator.…”

“…Dissolution analysis verified that the drug contained in the microparticles had a higher dissolution rate. Recently, Aquino et al [60] proposed the SAA process for the production of topic carrier microsystems based on Alginate-Pectin blends. Gentamicin sulphate was loaded as high soluble and hygroscopic antibiotic characterized by poor flowability.…”

Supercritical fluid assisted production of micrometric powders of the labile trypsin and chitosan/trypsin composite microparticles

“…Hence, more successful cases of protein micronization are needed to extend the application of the novel SAA-HCM process. Most of all, preparation of proteinloaded polymer microparticles using SAA/SAA-HCM has not been reported yet, although some other composite microparticles have been successfully coprecipitated, such as ampicillin trihydrate/ chitosan (Reverchon and Antonacci, 2007), Fe 3 O 4 /chitosan (Adami and Reverchon, 2012) and gentamicin/dextran (Aquino et al, 2013) microparticles.…”